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AB172114

Anti-Neurotensin antibody

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(2 Publications)

Rabbit Polyclonal Neurotensin antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NTS.

View Alternative Names

Neurotensin/neuromedin N, NTS

1 Images
Western blot - Anti-Neurotensin antibody (AB172114)
  • WB

Supplier Data

Western blot - Anti-Neurotensin antibody (AB172114)

All lanes:

Western blot - Anti-Neurotensin antibody (ab172114) at 1 µg/mL

Lane 1:

Neurotensin transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Rabbit IgG (H&L)-HRP at 1/7500 dilution

Predicted band size: 20 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NTS.

P30990

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurotensin also known by the abbreviation NT is a peptide neurotransmitter that consists of 13 amino acids giving it a relatively modest mass. It is well-known under the name NTS and is mainly expressed in the central nervous system especially within the hypothalamus midbrain and also found in peripheral tissues like the gastrointestinal tract. Neurotensin acts by binding to specific G-protein-coupled receptors such as NTSR1 to mediate its effects.
Biological function summary

The peptide neurotransmitter exhibits various functions in both the central and peripheral nervous systems. It can act as a neuromodulator affecting dopamine signaling and impacts the regulation of pain temperature and even food intake. Neurotensin forms part of complexes with other neurotransmitters and interacts closely with pathways related to dopamine suggesting a significant influence on mood and cognition.

Pathways

The interaction of neurotensin with dopamine pathways is particularly important. It plays a role in modulating the dopaminergic signaling cascades that involve receptor proteins like D2 dopamine receptors. Additionally neurotensin impacts the acute-phase response pathway altering the signaling dynamics in inflammation and immune response.

Neurotensin has connections to conditions such as schizophrenia and obesity. Its modulation of dopamine pathways links it to schizophrenia where altered dopamine signaling is evident with potential involvement of proteins like NTSR1 and D2 receptors. Additionally because neurotensin influences food intake and energy balance it relates to obesity with its effects mediated through interactions with other gut-derived peptides and receptors including ghrelin and leptin receptors.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
See full target information NTS
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

PloS one 19:e0299365 PubMed38875182

2024

A secreted proteomic footprint for stem cell pluripotency.

Applications

Unspecified application

Species

Unspecified reactive species

Philip A Lewis,Edina Silajdžić,Helen Smith,Nicola Bates,Christopher A Smith,Fabrizio E Mancini,David Knight,Chris Denning,Daniel R Brison,Susan J Kimber

International journal of molecular sciences 21: PubMed32630820

2020

Effects of DSPP and MMP20 Silencing on Adhesion, Metastasis, Angiogenesis, and Epithelial-Mesenchymal Transition Proteins in Oral Squamous Cell Carcinoma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jaya Aseervatham,Kalu U E Ogbureke
View all publications
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Product promise

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