AB233107

Anti-Neurotensin antibody

Name: Anti-Neurotensin antibody (ab233107) | Abcam
Brand: Abcam Limited
SKU: AB233107

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(6 Publications)

Rabbit Polyclonal Neurotensin antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NTS aa 1 to C-terminus.

View Alternative Names

Neurotensin/neuromedin N, NTS

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neurotensin antibody (AB233107)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neurotensin antibody (AB233107)

Formalin-fixed, paraffin-embedded human liver tissue stained for Neurotensin using ab233107 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Neurotensin antibody (AB233107)

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Western blot - Anti-Neurotensin antibody (ab233107) at 2 µg/mL

All lanes:

Mouse small intestine tissue lysate

Secondary

All lanes:

HRP-Linked goat anti-Rabbit IgG at 0.2 µg/mL

Predicted band size: 20 kDa

false

Supplier Data

Western blot - Anti-Neurotensin antibody (AB233107)

All lanes:

Western blot - Anti-Neurotensin antibody (ab233107) at 2 µg/mL

All lanes:

Mouse cerebrum tissue lysate

Secondary

All lanes:

HRP-Linked goat anti-Rabbit IgG at 0.2 µg/mL

Predicted band size: 20 kDa

false

Supplier Data

Western blot - Anti-Neurotensin antibody (AB233107)

All lanes:

Western blot - Anti-Neurotensin antibody (ab233107) at 2 µg/mL

All lanes:

Mouse stomach tissue lysate

Secondary

All lanes:

HRP-Linked goat anti-Rabbit IgG at 0.2 µg/mL

Predicted band size: 20 kDa

false

Supplier Data

Western blot - Anti-Neurotensin antibody (AB233107)

All lanes:

Western blot - Anti-Neurotensin antibody (ab233107) at 2 µg

All lanes:

Recombunant human Neurotensin protein

Predicted band size: 20 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human NTS aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P30990

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurotensin also known by the abbreviation NT is a peptide neurotransmitter that consists of 13 amino acids giving it a relatively modest mass. It is well-known under the name NTS and is mainly expressed in the central nervous system especially within the hypothalamus midbrain and also found in peripheral tissues like the gastrointestinal tract. Neurotensin acts by binding to specific G-protein-coupled receptors such as NTSR1 to mediate its effects.

Biological function summary

The peptide neurotransmitter exhibits various functions in both the central and peripheral nervous systems. It can act as a neuromodulator affecting dopamine signaling and impacts the regulation of pain temperature and even food intake. Neurotensin forms part of complexes with other neurotransmitters and interacts closely with pathways related to dopamine suggesting a significant influence on mood and cognition.

Pathways

The interaction of neurotensin with dopamine pathways is particularly important. It plays a role in modulating the dopaminergic signaling cascades that involve receptor proteins like D2 dopamine receptors. Additionally neurotensin impacts the acute-phase response pathway altering the signaling dynamics in inflammation and immune response.

Neurotensin has connections to conditions such as schizophrenia and obesity. Its modulation of dopamine pathways links it to schizophrenia where altered dopamine signaling is evident with potential involvement of proteins like NTSR1 and D2 receptors. Additionally because neurotensin influences food intake and energy balance it relates to obesity with its effects mediated through interactions with other gut-derived peptides and receptors including ghrelin and leptin receptors.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

See full target information NTS

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Translational psychiatry 15:361 PubMed41053001

2025

Restoration of NEXMIF expression rescues abnormalities in gene transcription, neuron maturation and autistic-like behaviors in Nexmif knockout mice.

Applications

Unspecified application

Species

Unspecified reactive species

KathrynAnn Odamah,Heng-Ye Man

eLife 12: PubMed37083757

2023

Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant mutation.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Hu,Bingna Zhou,Xiaoyun Lin,Qian Zhang,Feifei Guan,Lei Sun,Jiayi Liu,Ou Wang,Yan Jiang,Wei-Bo Xia,Xiaoping Xing,Mei Li

Frontiers in cell and developmental biology 11:1100788 PubMed36776563

2023

Increased adipose tissue lymphatic vessel density inhibits thermogenesis through elevated neurotensin levels.

Applications

Unspecified application

Species

Unspecified reactive species

Thien T Phan,Adri Chakraborty,Madison A Tatum,Ana Lima-Orellana,Andrea J Reyna,Joseph M Rutkowski

Frontiers in molecular neuroscience 15:828891 PubMed35571372

2022

Dysfunction of the Hippocampal-Lateral Septal Circuit Impairs Risk Assessment in Epileptic Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Cao,Chongyang Sun,Jianyu Huang,Peng Sun,Lulu Wang,Shuyu He,Jianxiang Liao,Zhonghua Lu,Yi Lu,Cheng Zhong

PeerJ 9:e11512 PubMed34141479

2021

Neuromedin U and neurotensin may promote the development of the tumour microenvironment in neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Daheng Yang,Xianwei Zhang,Zheqian Li,Fei Xu,Chenjie Tang,Hongbing Chen

Nucleic acids research 48:12135-12150 PubMed33196849

2020

Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Peiwei Chai,Jie Yu,Ruobing Jia,Xuyang Wen,Tianyi Ding,Xiaoyu Zhang,Hongyan Ni,Renbing Jia,Shengfang Ge,He Zhang,Xianqun Fan

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Neurotensin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neurotensin antibody (AB233107)

Western blot - Anti-Neurotensin antibody (AB233107)

Western blot - Anti-Neurotensin antibody (AB233107)

Western blot - Anti-Neurotensin antibody (AB233107)

Western blot - Anti-Neurotensin antibody (AB233107)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Secondary Antibodies

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

Product promise