AB183088

Anti-Neurotensin Receptor 1/NTSR1 antibody

Name: Anti-Neurotensin Receptor 1/NTSR1 antibody (ab183088) | Abcam
Brand: Abcam Limited
SKU: AB183088
Price: 535 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal Neurotensin Receptor 1/NTSR1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human NTSR1 aa 400 to C-terminus.

View Alternative Names

NTRR, NTSR1, Neurotensin receptor type 1, NT-R-1, NTR1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH

1 Images

Supplier Data

Western blot - Anti-Neurotensin Receptor 1/NTSR1 antibody (AB183088)

All lanes:

Western blot - Anti-Neurotensin Receptor 1/NTSR1 antibody (ab183088) at 1/200 dilution

Lane 1:

Jurkat cell lysate at 40 µg

Lane 2:

231 cell lysate at 40 µg

Secondary

All lanes:

Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution

Predicted band size: 46 kDa

true

Exposure time: 5min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human NTSR1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P30989

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/5000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurotensin Receptor 1 also known as NTSR1 functions as a G-protein coupled receptor (GPCR) that binds to the neuropeptide neurotensin. This protein consists of seven transmembrane domains typical of GPCRs and has a molecular mass of roughly 46 kDa. NTSR1 commonly expresses in the central nervous system particularly in the brain regions such as hypothalamus and basal ganglia and also in peripheral tissues like the gastrointestinal tract.

Biological function summary

NTSR1 influences signaling cascades that regulate various physiological processes. It forms part of a receptor-ligand complex with neurotensin a peptide that modulates neurotransmission and hormone regulation. Neurotensin and NTSR1 interaction can affect neurotransmitter release modulating pathways related to pain locomotion and thermoregulation. Researchers have observed significant roles of the receptor in neural proliferation as well.

Pathways

NTSR1 acts significantly in the dopaminergic and phosphatidylinositol signaling pathways. In the dopaminergic system NTSR1 interacts with dopamine D2 receptors influencing dopamine-mediated behaviors and responses. In phosphatidylinositol signaling it regulates downstream effectors like protein kinase C impacting cellular responses. These pathways integrate NTSR1 into broader signaling networks that control critical neuronal functions and responses.

NTSR1 has connections to certain neurological and psychiatric disorders such as schizophrenia and Parkinson's disease. Abnormal NTSR1 signaling affects dopaminergic neurotransmission which highlights its role in these conditions. Altered interactions with proteins like the dopamine D2 receptor contribute to the pathological symptoms observed in these diseases. Research into NTSR1 and its pathways may reveal targets for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed : 21725197, PubMed : 23140271, PubMed : 8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed : 21725197).

See full target information NTSR1

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of the American Chemical Society 146:13676-13688 PubMed38693710

2024

Affinity-Driven Aryl Diazonium Labeling of Peptide Receptors on Living Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sheryl Sharma,Michael J Naldrett,Makayla J Gill,James W Checco

Molecular carcinogenesis 58:2230-2240 PubMed31478563

2019

Neurotensin receptor 1 is a new therapeutic target for human undifferentiated pleomorphic sarcoma growth.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroto Tokumoto,Takao Setoguchi,Yoshinobu Saitoh,Hiromi Sasaki,Satoshi Nagano,Shingo Maeda,Akihide Tanimoto,Noboru Taniguchi

Molecular cancer 14:21 PubMed25644759

2015

Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Ouyang,Xueyang Gong,Hualiang Xiao,Ji Zhou,Minhui Xu,Yun Dai,Lunshan Xu,Hua Feng,Hongjuan Cui,Liang Yi

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Neurotensin Receptor 1/NTSR1 antibody

Western blot - Anti-Neurotensin Receptor 1/NTSR1 antibody (AB183088)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Secondary Antibodies

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise