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AB27380

Anti-Neurotensin Receptor 1/NTSR1 antibody [B-N6]

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(1 Publication)

Mouse Monoclonal Neurotensin Receptor 1/NTSR1 antibody. Suitable for Flow Cyt and reacts with Transfected cell line samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing NTSR1 protein.

View Alternative Names

NTRR, NTSR1, Neurotensin receptor type 1, NT-R-1, NTR1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH

1 Images
Flow Cytometry - Anti-Neurotensin Receptor 1/NTSR1 antibody [B-N6] (AB27380)
  • Flow Cyt

Unknown

Flow Cytometry - Anti-Neurotensin Receptor 1/NTSR1 antibody [B-N6] (AB27380)

Staining pattern of NTR transfected CHO cell line with ab27380.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

B-N6

Isotype

IgM

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing NTSR1 protein. The exact immunogen used to generate this antibody is proprietary information.

P30989

Specificity

Recognises the membrane protein.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" }, "Transfected cell line": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.</p>" } } }
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Properties and storage information

Form
Liquid
Purification notes
Gel filtration
Storage buffer
pH: 7.3 - 7.5 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurotensin Receptor 1 also known as NTSR1 functions as a G-protein coupled receptor (GPCR) that binds to the neuropeptide neurotensin. This protein consists of seven transmembrane domains typical of GPCRs and has a molecular mass of roughly 46 kDa. NTSR1 commonly expresses in the central nervous system particularly in the brain regions such as hypothalamus and basal ganglia and also in peripheral tissues like the gastrointestinal tract.
Biological function summary

NTSR1 influences signaling cascades that regulate various physiological processes. It forms part of a receptor-ligand complex with neurotensin a peptide that modulates neurotransmission and hormone regulation. Neurotensin and NTSR1 interaction can affect neurotransmitter release modulating pathways related to pain locomotion and thermoregulation. Researchers have observed significant roles of the receptor in neural proliferation as well.

Pathways

NTSR1 acts significantly in the dopaminergic and phosphatidylinositol signaling pathways. In the dopaminergic system NTSR1 interacts with dopamine D2 receptors influencing dopamine-mediated behaviors and responses. In phosphatidylinositol signaling it regulates downstream effectors like protein kinase C impacting cellular responses. These pathways integrate NTSR1 into broader signaling networks that control critical neuronal functions and responses.

NTSR1 has connections to certain neurological and psychiatric disorders such as schizophrenia and Parkinson's disease. Abnormal NTSR1 signaling affects dopaminergic neurotransmission which highlights its role in these conditions. Altered interactions with proteins like the dopamine D2 receptor contribute to the pathological symptoms observed in these diseases. Research into NTSR1 and its pathways may reveal targets for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed : 21725197, PubMed : 23140271, PubMed : 8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed : 21725197).
See full target information NTSR1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of the United States of America 101:4560-5 PubMed15070757

2004

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.

Applications

Unspecified application

Species

Unspecified reactive species

Frank A W Verreck,Tjitske de Boer,Dennis M L Langenberg,Marieke A Hoeve,Matthijs Kramer,Elena Vaisberg,Robert Kastelein,Arend Kolk,René de Waal-Malefyt,Tom H M Ottenhoff
View all publications
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