Anti-Neurotensin Receptor 2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Neurotensin Receptor 2 often abbreviated as NTSR2 functions mechanically by binding to the neurotensin peptide. Identified as a G-protein coupled receptor it facilitates signal transduction across cell membranes. NTSR2 has a molecular mass of approximately 50 kDa. This receptor is expressed in the central nervous system particularly in the brain regions such as the hypothalamus and amygdala and also found in peripheral tissues.

Biological function summary

NTSR2 influences various neural processes including neurotransmission and modulation of dopamine pathways. It interacts with neurotensin a tridecapeptide known for its role as a neurotransmitter and neuromodulator. NTSR2 usually not found in complex with other receptors still operates effectively to initiate intracellular signaling cascades affecting neuronal excitability and physiological responses like body temperature and pain perception.

Pathways

NTSR2 plays a prominent role in neurotensin-mediated signaling pathways. These pathways primarily involve the regulation of dopamine an important neurotransmitter involved in several brain functions. NTSR2 acts alongside other related proteins such as Neurotensin Receptor 1 (NTSR1) helping fine-tune dopaminergic signaling which is essential for maintaining balance within various neural circuits.

Associated diseases and disorders

NTSR2 has been linked to conditions such as schizophrenia and certain types of cancer. The receptor's involvement in dopamine signaling implicates it in schizophrenia a disorder characterized by imbalances in dopaminergic activity. In cancer particularly pancreatic cancer NTSR2 expression can influence tumor progression. The protein's interaction with Neurotensin Receptor 1 also illustrates its importance in understanding the complex mechanisms behind these diseases.