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AB48273

Anti-Neurotensin Receptor 2 antibody

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(1 Publication)

Rabbit Polyclonal Neurotensin Receptor 2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NTSR2 aa 350 to C-terminus.

View Alternative Names

Neurotensin receptor type 2, NT-R-2, NTR2, Levocabastine-sensitive neurotensin receptor, NTSR2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neurotensin Receptor 2 antibody (AB48273)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neurotensin Receptor 2 antibody (AB48273)

Immunostaining of Neurotensin Receptor 2 from paraffin embedded parietal cells of Human gastric mucosa tissue sections using ab48273.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human NTSR2 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O95665

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Preservative: 0.05% Sodium azide Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurotensin Receptor 2 often abbreviated as NTSR2 functions mechanically by binding to the neurotensin peptide. Identified as a G-protein coupled receptor it facilitates signal transduction across cell membranes. NTSR2 has a molecular mass of approximately 50 kDa. This receptor is expressed in the central nervous system particularly in the brain regions such as the hypothalamus and amygdala and also found in peripheral tissues.
Biological function summary

NTSR2 influences various neural processes including neurotransmission and modulation of dopamine pathways. It interacts with neurotensin a tridecapeptide known for its role as a neurotransmitter and neuromodulator. NTSR2 usually not found in complex with other receptors still operates effectively to initiate intracellular signaling cascades affecting neuronal excitability and physiological responses like body temperature and pain perception.

Pathways

NTSR2 plays a prominent role in neurotensin-mediated signaling pathways. These pathways primarily involve the regulation of dopamine an important neurotransmitter involved in several brain functions. NTSR2 acts alongside other related proteins such as Neurotensin Receptor 1 (NTSR1) helping fine-tune dopaminergic signaling which is essential for maintaining balance within various neural circuits.

NTSR2 has been linked to conditions such as schizophrenia and certain types of cancer. The receptor's involvement in dopamine signaling implicates it in schizophrenia a disorder characterized by imbalances in dopaminergic activity. In cancer particularly pancreatic cancer NTSR2 expression can influence tumor progression. The protein's interaction with Neurotensin Receptor 1 also illustrates its importance in understanding the complex mechanisms behind these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
See full target information NTSR2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Neoplasia (New York, N.Y.) 15:1231-40 PubMed24339735

2013

Identification of molecular tumor markers in renal cell carcinomas with TFE3 protein expression by RNA sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Dorothee Pflueger,Andrea Sboner,Martina Storz,Jasmine Roth,Eva Compérat,Elisabeth Bruder,Mark A Rubin,Peter Schraml,Holger Moch
View all publications
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Product promise

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