Anti-Neutrophil antibody [NIMP-R14]

Product details

The Ly-6G/-6C locus encodes a family of Ly-6 proteins including Ly-6G and Ly-6C. Ly-6 antigens have a molecular weight between 15,000 and 18,000. Ly-6G is together with Ly-6C a component of the myeloid differentiation antigen Gr-1. Ly-6G is a GPI-anchored protein and is a good marker of peripheral neutrophils. Although predominantly presents on neutrophils, it is also expressed on a subset of eosinophils, differentiating premonocytes and plasmacytoid dendritic cells. Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon gamma, and may play a role in the development and maturation of lymphocytes. It is expressed on bone marrow cells, monocytes/macrophages, neutrophils, endothelial cells, and T cell subsets. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. However, the physiological role of Ly-6G alone remains still unclear. The monoclonal antibody NIMP-R14 has been successfully used to stain polymorphonuclear (PMN) cells and monocytes for fluorescent activated cell sorting and in frozen and paraffin sections. Treatment with antibodies in vivo leads to neutropenia and has inhibitory effect on local immune responses. Furthermore, it has been shown to be useful for depletion of neutrophils in mice. It depletes neutrophils as soon as 6 hours after injection and up to 6 days.

Product Specifications
Anti-Neutrophil antibody [NIMP-R14] (ab2557) is a rat monoclonal antibody and is validated for use in IHC-Fr in mouse samples.
Anti-Neutrophil antibody [NIMP-R14] (ab2557) specifically detects Neutrophil (UniProt ID: Q63317; Molecular weight: 9kDa) and is sold in 50 µg selling sizes.

Quality and Validation
Abcam's high quality validation processes ensure Anti-Neutrophil antibody [NIMP-R14] (ab2557) has high sensitivity and specificity.
Anti-Neutrophil antibody [NIMP-R14] (ab2557) has been cited over 250 times in peer reviewed journals and is trusted by the scientific community.
Anti-Neutrophil antibody [NIMP-R14] (ab2557) has 25 independent reviews from customers.

Related Products
Conjugation-ready, carrier free format available for antibody clone NIMP-R14 - ab223792.