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AB192765

Anti-Neutrophil defensin 4 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal Neutrophil defensin 4 antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DEFA4.

View Alternative Names

DEF4, DEFA4, Defensin alpha 4, Corticostatin HP-4, HNP-4, Neutrophil defensin 4, HP-4

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neutrophil defensin 4 antibody - N-terminal (AB192765)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neutrophil defensin 4 antibody - N-terminal (AB192765)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labeling Neutrophil defensin 4 with ab192765 at 10μg/mL.

Western blot - Anti-Neutrophil defensin 4 antibody - N-terminal (AB192765)
  • WB

Supplier Data

Western blot - Anti-Neutrophil defensin 4 antibody - N-terminal (AB192765)

All lanes:

Western blot - Anti-Neutrophil defensin 4 antibody - N-terminal (ab192765) at 1/500 dilution

Lane 1:

MCF7 cell lysate

Lane 2:

Mouse spleen tissue lysate

Lane 3:

Rat spleen tissue lysate

Predicted band size: 10 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human DEFA4. The exact immunogen used to generate this antibody is proprietary information.

P12838

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neutrophil defensin 4 also known as human neutrophil peptide 4 (HNP-4) is a small antimicrobial peptide with a mass of approximately 3.5 kDa. It belongs to the defensin family and is specifically expressed in neutrophils a type of white blood cell important for the immune response. Neutrophil defensin 4 helps in the direct killing of microbes by disrupting their cell membranes. It accumulates in the azurophilic granules of neutrophils and releases during phagocytosis to provide its antimicrobial effects.
Biological function summary

Neutrophil defensin 4 plays a role in the innate immune system providing a first line of defense against bacterial fungal and some viral pathogens. It is not part of a larger protein complex but works independently through its peptide structure. The defensins including neutrophil defensin 4 are unique due to their ability to act directly on microbial surfaces which limits the development of resistance in these pathogens. This peptide binds to microbial membranes and forms pore-like structures that compromise cell integrity.

Pathways

Neutrophil defensin 4 is involved in the immune response pathway specifically as part of the innate immunity process. It associates with other antimicrobial peptides like defensin alpha 1 and defensin beta 1 to enhance the microbicidal activity of neutrophils. Additionally it intersects with inflammatory signaling pathways by modulating the activity of cytokines and chemokines contributing to immune cell recruitment during infection.

Neutrophil defensin 4 has connections to cystic fibrosis and inflammatory bowel disease. In cystic fibrosis the altered expression and function of neutrophil defensin 4 and related peptides like beta defensins may contribute to persistent bacterial infections in the lungs due to a compromised mucosal barrier. In inflammatory bowel disease imbalances in neutrophil defensin 4 levels can exacerbate intestinal inflammation and mucosal damage with interactions noted between defensin expression and cytokines like interleukin-8 that lead to inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi (PubMed : 15317502, PubMed : 15616305, PubMed : 2500436, PubMed : 2501794, PubMed : 30658057). Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro) (PubMed : 15317502, PubMed : 15616305, PubMed : 17088326, PubMed : 2500436, PubMed : 2501794, PubMed : 30658057). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef (PubMed : 15620707, PubMed : 30658057). Protects blood cells against infection with HIV-1 (in vitro) (PubMed : 15620707). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro) (PubMed : 30658057). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro) (PubMed : 2843187).
See full target information DEFA4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 16:1613438 PubMed40978465

2025

Abnormal Ca handling and reduced I contribute to citalopram-induced QT prolongation and cardiac arrhythmias.

Applications

Unspecified application

Species

Unspecified reactive species

Yangpeng Li,Jiamin Xie,Yuqing Zheng,Jianhong Li,Min Zhao,Li Liu,Hongping Shen,Ming Lei,Xiaoqiu Tan,Juan Xiao,Xueru Liu,Tangting Chen
View all publications
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Product promise

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