Rabbit Recombinant Monoclonal NFkB Inducing Kinase NIK antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MAP3K14 aa 700-900.
Images
![Western blot - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (AB203568), expandable thumbnail](https://content.abcam.com/products/images/nfkb-inducing-kinase-nik-antibody-3h31l48-ab203568--western-blot-img147165.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (AB203568)")
![Immunocytochemistry/ Immunofluorescence - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (AB203568), expandable thumbnail](https://content.abcam.com/products/images/nfkb-inducing-kinase-nik-antibody-3h31l48-ab203568--immunocytochemistry-immunofluorescence-img41844.jpg/_jcr_content/renditions/webp-475.webp "Immunocytochemistry/ Immunofluorescence - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (AB203568)")
Publications
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- PLoS pathogens 18:e10101102022Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFengchun Ye,David Alvarez-Carbonell,Kien Nguyen,Konstantin Leskov,Yoelvis Garcia-Mesa,Sheetal Sreeram,Saba Valadkhan,Jonathan KarnPubMed 35797416
- BioMed research international 2020:14815722020HuR Affects Proliferation and Apoptosis of Chronic Lymphocytic Leukemia Cells via NF-B Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKai Xiao et. al.PubMed 32908868
- International journal of molecular medicine 38:1661-16722016Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Fragment Protein within Human MAP3K14 aa 700-900. The exact immunogen used to generate this antibody is proprietary information. Database link Q99558
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10.00000-20.00000 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 4.00000-6.00000 µg/mL | Notes - |
Associated Products
Select an associated product type
4 products for Alternative Product
Target data
Function
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner.
Alternative names
NIK, MAP3K14, Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, Serine/threonine-protein kinase NIK, HsNIK
Recommended products
Rabbit Recombinant Monoclonal NFkB Inducing Kinase NIK antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MAP3K14 aa 700-900.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Fragment Protein within Human MAP3K14 aa 700-900. The exact immunogen used to generate this antibody is proprietary information. Database link Q99558
- Clone number
- 3H31L48
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
![Western blot - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (ab203568), expandable thumbnail](https://content.abcam.com/products/images/nfkb-inducing-kinase-nik-antibody-3h31l48-ab203568--western-blot-img147165.jpg "Western blot - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (ab203568)")
Western blot - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (ab203568)
Lane 1: anti FLAG tag antibody
Lane 2: Western blot - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (ab203568) at 15 µg/mL
All lanes: Flag tagged NIK transfected 293 cell lysate
Predicted band size: 104 kDa
![Immunocytochemistry/ Immunofluorescence - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (ab203568), expandable thumbnail](https://content.abcam.com/products/images/nfkb-inducing-kinase-nik-antibody-3h31l48-ab203568--immunocytochemistry-immunofluorescence-img41844.jpg "Immunocytochemistry/ Immunofluorescence - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (ab203568)")
Immunocytochemistry/ Immunofluorescence - Anti-NFkB Inducing Kinase NIK antibody [3H31L48] (ab203568)
Immunohistochemical analysis of non-transfected (left) and NIK transfected 293 cells (right) labeling NIK using ab203568 at 5 μg/mL. Alexa Fluor® 488 Goat anti-Rabbit at 1/1000 dilution was used as secondary antibody (green). Hoescht staining of nucleus (blue).
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