Goat Polyclonal Nicotinic Acetylcholine Receptor alpha 7 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CHRNA7 aa 300-400.
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Publications
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- Frontiers in pharmacology 12:7062252021Cytisine Exerts an Anti-Epileptic Effect via α7nAChRs in a Rat Model of Temporal Lobe Epilepsy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing-Jun Zheng,Teng-Yue Zhang,Hong-Tao Liu,Ze-Xin Huang,Jing-Mei Teng,Jing-Xian Deng,Jia-Gui Zhong,Xu Qian,Xin-Wen Sheng,Ji-Qiang Ding,Shu-Qiao He,Xin Zhao,Wei-Dong Ji,De-Feng Qi,Wei Li,Mei ZhangPubMed 34248648
- Frontiers in immunology 12:6318812021New Pathways for the Skin's Stress Response: The Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine Production in Mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChristoph M Ertle,Frank R Rommel,Susanne Tumala,Yasuhiro Moriwaki,Jochen Klein,Johannes Kruse,Uwe Gieler,Eva M J PetersPubMed 33815383
- EBioMedicine 45:495-5102019Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNatalia Schneider Nunes et. al.PubMed 31253515
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99.48% Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human CHRNA7 aa 300-400. The exact immunogen used to generate this antibody is proprietary information. Database link P36544
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Chicken | Predicted |
| Cow | Predicted |
| Dog | Predicted |
| Pig | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 3.00000-6.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow, Dog, Pig, Chicken | Dilution info - | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Alternative names
NACHRA7, CHRNA7, Neuronal acetylcholine receptor subunit alpha-7
Recommended products
Goat Polyclonal Nicotinic Acetylcholine Receptor alpha 7 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CHRNA7 aa 300-400.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99.48% Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human CHRNA7 aa 300-400. The exact immunogen used to generate this antibody is proprietary information. Database link P36544
- Purification technique
- Affinity purification Protein G
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Nicotinic Acetylcholine Receptor alpha 7 (nAChR α7) is an important ligand-gated ion channel involved in neurotransmission. It is commonly known by its alternate name α7-nAChR. This receptor plays a critical role in fast synaptic transmission and is activated by the neurotransmitter acetylcholine. The nAChR α7 is a homomeric receptor meaning it is composed entirely of alpha 7 subunits each with a molecular mass of approximately 57 kDa. It is expressed predominantly in the central nervous system especially in the brain but also found in other tissues like the immune system.
- Biological function summary
The nAChR α7 facilitates the influx of cations like calcium and sodium upon activation influencing cellular signaling events. As part of the larger family of nicotinic acetylcholine receptors it functions within a pentameric complex structure. The receptor is essential for cognitive processes including attention and memory by modulating neurotransmitter release and plasticity. It also interacts with other neurotransmitter pathways and may play a role in anti-inflammatory processes due to its expression in non-neuronal tissues.
- Pathways
The nAChR α7 is involved in the cholinergic signaling pathway and the broader calcium signaling pathway. It contributes to the regulation of intracellular calcium levels which are important for various cellular functions. The receptor works alongside other proteins such as bungarotoxin-sensitive nAChRs and muscarinic acetylcholine receptors (mAChRs) to mediate complex neurotransmitter systems. The interplay between these receptors highlights the receptor's importance in maintaining synaptic function and plasticity.
- Associated diseases and disorders
Research indicates a connection between nAChR α7 and neurodegenerative diseases like Alzheimer’s disease and schizophrenia. The receptor's dysfunction or altered expression has been linked to cognitive deficits associated with these conditions. In Alzheimer's disease the interaction of nAChR α7 with amyloid-beta peptides may contribute to neurotoxicity. Additionally the receptor's association with cytokine release in immune cells suggests a potential role in inflammatory disorders. Its linkage with other neurotransmitter systems such as the involvement of nAChR agonists further demonstrates the receptor's relevance to these neurological and immune-associated diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab110851)
ab110851 at 5μg/ml staining Nicotinic Acetylcholine Receptor alpha 7 in Formalin-fixed, Paraffin-embedded Human Brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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