Rabbit Polyclonal Nicotinic Acetylcholine Receptor gamma antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CHRNG aa 250-500.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
ACHRG, CHRNG, Acetylcholine receptor subunit gamma
Rabbit Polyclonal Nicotinic Acetylcholine Receptor gamma antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CHRNG aa 250-500.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
The Nicotinic Acetylcholine Receptor gamma also known as the γ-subunit of nAChR is an integral member of the nicotinic acetylcholine receptor family. This receptor with a molecular mass of approximately 57 kDa functions as a ligand-gated ion channel in the nervous system. The γ-subunit is essential for the assembly and operation of the receptor complex predominantly found in skeletal muscle tissues. Expression of this receptor varies during development with a significant presence in embryonic muscle cells.
The γ-subunit contributes to the functionality of the nicotinic acetylcholine receptor which is important for neuromuscular transmission. This subunit is part of the pentameric receptor complex generally comprising alpha beta delta and epsilon or gamma subunits. The γ-subunit helps facilitate the rapid transmission of electrical signals by allowing sodium and potassium ions to pass through the cell membrane following acetylcholine binding. This process is fundamental in muscle contraction and development especially in early developmental stages before the ε-subunit expression increases.
Nicotinic Acetylcholine Receptor gamma participates in synaptic pathways controlling muscle contraction and cholinergic signaling. It interacts intricately with the neuromuscular junction pathway where it aids in the transmission of signals from nerve terminals to muscle fibers. This receptor also shares functional similarities with proteins like the Muscarinic Acetylcholine Receptors contributing to varied cholinergic neurotransmission roles.
Alterations in Nicotinic Acetylcholine Receptor gamma expression or function associate with certain muscle dystrophies and congenital myasthenic syndromes. Variants or defects in the gamma subunit have implications in diseases such as Arthrogryposis Multiplex Congenita linked to abnormal neuromuscular junction development. The receptor's interaction with proteins such as rapsyn involved in receptor clustering at the neuromuscular junction highlights its role in this condition.
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10% SDS PAGE
All lanes: Western blot - Anti-Nicotinic Acetylcholine Receptor gamma antibody (ab151627) at 1/1000 dilution
Lane 1: 293T whole cell lysate at 30 µg
Lane 2: A431 whole cell lysate at 30 µg
Predicted band size: 58 kDa
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