Anti-Nipah virus Glycoprotein G antibody [EPR29883-707]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Nipah virus Glycoprotein G also known as NiV-G serves mechanically as an essential viral attachment protein. This glycoprotein with a mass of approximately 70 kDa is expressed on the surface of the Nipah virus envelope. It facilitates viral entry into host cells by binding to ephrin-B2 and ephrin-B3 receptors. Its activity is necessary for initiating infection in host species including humans and animals.

Biological function summary

Glycoproteins like Nipah virus Glycoprotein G play a significant role in viral life cycles. NiV-G exists as a part of a complex and works in conjunction with other viral proteins especially the fusion protein F to mediate membrane fusion. By binding selectively to host cell receptors it determines the host range and tissue tropism of the virus. The interaction with host receptors also impacts the viral spread within the host organism.

Pathways

Several viral entry mechanisms involve Nipah virus Glycoprotein G. The fusion process involving this glycoprotein and the fusion protein (F protein) is a part of the cell entry pathway. This pathway is critical for the virus to access intracellular machinery. Additionally NiV-G is connected with signaling pathways through its interaction with ephrin receptors contributing to viral pathogenesis and immune evasion.

Associated diseases and disorders

Nipah virus Glycoprotein G is significantly associated with Nipah virus infection leading to severe encephalitis and respiratory illness. This protein through its interaction with ephrin-B2 and ephrin-B3 contributes to the virus's ability to cause widespread cell damage in the brain and respiratory tissues. Moreover the glycoprotein F works in concert with NiV-G to facilitate transmission and heightened virulence of the infection highlighting the critical role of these proteins in disease progression.