Anti-Nipah virus Nucleoprotein antibody [HL1436]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NiV NP also known as Nipah nucleoprotein is one of the key structural proteins of the Nipah virus (NiV) a paramyxovirus of significant concern. The nucleoprotein has a molecular mass of approximately 55 kDa and is expressed within the host cells infected by the virus. NiV NP plays a mechanical role by encapsidating the viral RNA forming the ribonucleoprotein (RNP) complex important for the virus's replication and transcription processes. This encapsidation shields viral RNA from host cell defenses and aids in the virus's lifecycle progression.

Biological function summary

NiV NP functions in the NiV replication complex playing an essential role in the transcription and replication of the viral genome. It forms helical nucleocapsids with viral RNA working closely with other proteins such as the phosphoprotein (P) and large protein (L). NiV NP provides a scaffold for the polymerase complex and modulates its activity. It interacts with cellular mechanisms to evade the host immune response ensuring enhanced stability and survival of the virus within host cells.

Pathways

NiV NP is involved in the viral replication and transcription pathway facilitating Nipah virus's successful reproduction and spread. The nucleoprotein interacts primarily with the viral phosphoprotein (P) and plays a role in modulating the activity of the polymerase complex (Rabies P and L proteins also serve a somewhat similar function in their pathways). This involvement highlights the nucleoprotein’s critical role in maintaining the efficiency of viral genomic synthesis and transcription key steps in the viral replication cycle.

Associated diseases and disorders

NiV NP is closely linked to the pathogenesis of Nipah virus infection which can lead to severe febrile illness and encephalitis in humans. The protein's interactions and protection of the viral genome contribute to the virus's pathogenicity. Its role in the virus's lifecycle correlates to the host's immune evasion and disease progression. NiV NP is therefore a significant target in understanding the Nipah virus's disease mechanisms and potential therapeutic interventions. Additionally its function ties with other viral proteins like the fusion protein (F) and glycoprotein (G) which together mediate cell entry and spread of the virus exacerbating the disease severity.