Mouse Monoclonal Nitrotyrosine antibody. Suitable for ICC, ELISA, WB and reacts with Chemical samples. Cited in 9 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to Nitrotyrosine.
Preservative: 0.02% Sodium azide
Constituents: Tissue culture supernatant
| ICC | ELISA | WB | |
|---|---|---|---|
| Chemical | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Chemical | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Chemical | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Chemical | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
Select an associated product type
Mouse Monoclonal Nitrotyrosine antibody. Suitable for ICC, ELISA, WB and reacts with Chemical samples. Cited in 9 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to Nitrotyrosine.
Preservative: 0.02% Sodium azide
Constituents: Tissue culture supernatant
This antibody reacts with free and bound Nitrotyrosine.
Nitrotyrosine also known as 3-nitrotyrosine is a marker for nitrosative stress and oxidative damage. It comes from the nitration of tyrosine an amino acid primarily through the action of reactive nitrogen species. Nitrotyrosine can be found in proteins and its molecular mass varies depending on the protein context. It is present across various tissues and fluid samples within the body particularly where high oxidative stress occurs.
Nitrotyrosine acts as an indicator of cellular damage and protein modification due to stress conditions. When proteins have nitrotyrosine residues their function might change which can lead to cellular signaling disruption. Nitrotyrosine is not usually part of a specific complex but it affects proteins and enzymes by altering their activity and stability contributing to larger stress response mechanisms.
Proteins modified by nitrotyrosine are involved in cellular pathways related to oxidative stress and inflammation. Particularly pathways like the nitric oxide synthase pathway and the inflammatory response pathway include nitrotyrosine-modified proteins. It is related to proteins such as nitric oxide synthase (NOS) and superoxide dismutase (SOD) important in managing oxidative balance and stress responses in cells.
Nitrotyrosine is significantly linked to diseases related to oxidative stress such as cardiovascular disease and neurodegenerative disorders. These conditions often have increased levels of nitrotyrosine indicating heightened oxidative damage. Through these diseases nitrotyrosine connects with proteins like amyloid-beta in neurodegenerative disorders and endothelial nitric oxide synthase (eNOS) in cardiovascular diseases reflecting the impact of oxidative stress on these proteins.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com