AB42789

Anti-Nitrotyrosine antibody

Name: Anti-Nitrotyrosine antibody (ab42789) | Abcam
Brand: Abcam Limited
SKU: AB42789
Price: 565 USD
Availability: InStock
Rating: 4 (2 reviews)

(2 Reviews)

(23 Publications)

Rabbit Polyclonal Nitrotyrosine antibody. Suitable for ELISA, WB, IHC-FoFr, IHC-P and reacts with Chemical samples. Cited in 23 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to Nitrotyrosine.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Applications

WB, IHC-FoFr, IHC-P, ELISA

applications

Specificity

This antibody reacts with free and bound nitrotyrosine. There is no cross reaction with free or bound tyrosine

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Reactivity data

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You may be interested in:

AB116691

3-Nitrotyrosine ELISA Kit

1 Reviews

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Why is this recommended?

We recommend this product because it’s often used in the same experiment or related research.

We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Nitrotyrosine also known as 3-nitrotyrosine is a marker for nitrosative stress and oxidative damage. It comes from the nitration of tyrosine an amino acid primarily through the action of reactive nitrogen species. Nitrotyrosine can be found in proteins and its molecular mass varies depending on the protein context. It is present across various tissues and fluid samples within the body particularly where high oxidative stress occurs.

Biological function summary

Nitrotyrosine acts as an indicator of cellular damage and protein modification due to stress conditions. When proteins have nitrotyrosine residues their function might change which can lead to cellular signaling disruption. Nitrotyrosine is not usually part of a specific complex but it affects proteins and enzymes by altering their activity and stability contributing to larger stress response mechanisms.

Pathways

Proteins modified by nitrotyrosine are involved in cellular pathways related to oxidative stress and inflammation. Particularly pathways like the nitric oxide synthase pathway and the inflammatory response pathway include nitrotyrosine-modified proteins. It is related to proteins such as nitric oxide synthase (NOS) and superoxide dismutase (SOD) important in managing oxidative balance and stress responses in cells.

Nitrotyrosine is significantly linked to diseases related to oxidative stress such as cardiovascular disease and neurodegenerative disorders. These conditions often have increased levels of nitrotyrosine indicating heightened oxidative damage. Through these diseases nitrotyrosine connects with proteins like amyloid-beta in neurodegenerative disorders and endothelial nitric oxide synthase (eNOS) in cardiovascular diseases reflecting the impact of oxidative stress on these proteins.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Nitrotyrosine

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Publications (23)

Recent publications for all applications. Explore the full list and refine your search

Foods (Basel, Switzerland) 11: PubMed36553735

2022

Proteomic Profiling of Major Peanut Allergens and Their Post-Translational Modifications Affected by Roasting.

Applications

Unspecified application

Species

Unspecified reactive species

Teodora Đukić,Katarina Smiljanić,Jelena Mihailović,Ivana Prodić,Danijela Apostolović,Shu-Hua Liu,Michelle M Epstein,Marianne van Hage,Dragana Stanić-Vučinić,Tanja Ćirković Veličković

Frontiers in cardiovascular medicine 9:1064375 PubMed36465470

2022

Slow flow induces endothelial dysfunction by regulating thioredoxin-interacting protein-mediated oxidative metabolism and vascular inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Yongshun Wang,Jingjin Liu,Huadong Liu,Xin Sun,Ruimian Chen,Bihong Liao,Xiaoyi Zeng,Xiaoxin Zhang,Shaohong Dong,Zhengyuan Xia,Jie Yuan

iScience 25:103707 PubMed35036884

2022

Enterocyte superoxide dismutase 2 deletion drives obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Oihane Garcia-Irigoyen,Fabiola Bovenga,Marilidia Piglionica,Elena Piccinin,Marica Cariello,Maria Arconzo,Claudia Peres,Paola Antonia Corsetto,Angela Maria Rizzo,Marta Ballanti,Rossella Menghini,Geltrude Mingrone,Philippe Lefebvre,Bart Staels,Takuji Shirasawa,Carlo Sabbà,Gaetano Villani,Massimo Federici,Antonio Moschetta

International journal of molecular sciences 22: PubMed34281287

2021

Fibroblast Growth Factor Type 1 Ameliorates High-Glucose-Induced Oxidative Stress and Neuroinflammation in Retinal Pigment Epithelial Cells and a Streptozotocin-Induced Diabetic Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Hsin-Wei Huang,Chung-May Yang,Chang-Hao Yang

Biology of sex differences 12:37 PubMed34039432

2021

Network analysis of the left anterior descending coronary arteries in swim-trained rats by an in situ video microscopic technique.

Applications

Unspecified application

Species

Unspecified reactive species

Marianna Török,Petra Merkely,Anna Monori-Kiss,Eszter Mária Horváth,Réka Eszter Sziva,Borbála Péterffy,Attila Jósvai,Alex Ali Sayour,Attila Oláh,Tamás Radovits,Béla Merkely,Nándor Ács,György László Nádasy,Szabolcs Várbíró

The Journal of neuroscience : the official journal of the Society for Neuroscience 41:3731-3746 PubMed33563726

2021

REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.

Applications

Unspecified application

Species

Unspecified reactive species

Brent J Ryan,Nora Bengoa-Vergniory,Matthew Williamson,Ecem Kirkiz,Rosalind Roberts,Gabriele Corda,Maximilian Sloan,Saba Saqlain,Marta Cherubini,Josse Poppinga,Helle Bogtofte,Milena Cioroch,Svenja Hester,Richard Wade-Martins

Molecular metabolism 43:101123 PubMed33227495

2020

Inhibition of mitochondrial fission and iNOS in the dorsal vagal complex protects from overeating and weight gain.

Applications

Unspecified application

Species

Unspecified reactive species

Bianca Patel,Lauryn E New,Joanne C Griffiths,Jim Deuchars,Beatrice M Filippi

Antioxidants (Basel, Switzerland) 9: PubMed33076449

2020

Vitamin D Deficiency Induces Elevated Oxidative and Biomechanical Damage in Coronary Arterioles in Male Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Réka Eszter Sziva,Zoltán Fontányi,Éva Pál,Leila Hadjadj,Anna Monori-Kiss,Eszter Mária Horváth,Rita Benkő,Attila Magyar,Andrea Heinzlmann,Zoltán Benyó,György L Nádasy,Szabolcs Várbíró

Cells 9: PubMed33050629

2020

Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Volker Adams,Victoria Gußen,Sergey Zozulya,André Cruz,Anselmo Moriscot,Axel Linke,Siegfried Labeit

Journal of cellular physiology 236:3073-3082 PubMed32974910

2020

TSPO ligand FGIN-1-27 controls priapism in sickle cell mice via endogenous testosterone production.

Applications

Unspecified application

Species

Unspecified reactive species

Biljana Musicki,Serkan Karakus,Justin D La Favor,Haolin Chen,Fabio H Silva,Mikael Sturny,Barry R Zirkin,Arthur L Burnett

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

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biotin-nitrotyrosine-antibody-8c73-ab24496

(2 reviews)

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