Anti-Nitrotyrosine antibody [HM.11]
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(84 Publications)
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nitrotyrosine antibody [HM.11] (AB7048)
ab7048 at 2 μg/ml staining Nitrotyrosine in Human liver from a severely obese patient. ab7048 was incubated for 1 hour at room temperature.
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Biological function summary
Nitrotyrosine acts as an indicator of cellular damage and protein modification due to stress conditions. When proteins have nitrotyrosine residues their function might change which can lead to cellular signaling disruption. Nitrotyrosine is not usually part of a specific complex but it affects proteins and enzymes by altering their activity and stability contributing to larger stress response mechanisms.
Pathways
Proteins modified by nitrotyrosine are involved in cellular pathways related to oxidative stress and inflammation. Particularly pathways like the nitric oxide synthase pathway and the inflammatory response pathway include nitrotyrosine-modified proteins. It is related to proteins such as nitric oxide synthase (NOS) and superoxide dismutase (SOD) important in managing oxidative balance and stress responses in cells.
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Publications (84)
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Frontiers in pharmacology 16:1551533 PubMed40371343
2025
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Frontiers in cellular neuroscience 19:1571428 PubMed40313591
2025
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International journal of molecular sciences 25: PubMed39409096
2024
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International journal of molecular sciences 25: PubMed39126079
2024
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Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 19:36 PubMed39042202
2024
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Neurobiology of disease 196:106506 PubMed38648865
2024
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Antioxidants (Basel, Switzerland) 13: PubMed38247537
2024
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Journal of translational medicine 21:799 PubMed37946197
2023
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eLife 12: PubMed37267120
2023
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International journal of molecular sciences 23: PubMed36499244
2022
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