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AB220898

Anti-NKG2C antibody

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(1 Publication)

Rabbit Polyclonal NKG2C antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KLRC2 aa 200 to C-terminus.

View Alternative Names

CD159c, NKG2C, KLRC2, NKG2-C type II integral membrane protein, CD159 antigen-like family member C, NK cell receptor C, NKG2-C-activating NK receptor

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-NKG2C antibody (AB220898)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NKG2C antibody (AB220898)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-2 OS cells labeling NKG2C with ab220898 at 4 μg/mL (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human KLRC2 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P26717

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Chimpanzee": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NKG2C also known as CD159c is a receptor protein that plays an important role in immune responses. This protein has an approximate mass of 30 kDa and is usually found on the surface of natural killer (NK) cells. NKG2C belongs to the family of C-type lectin receptors and forms heterodimers with the signaling adaptor protein DAP12. These heterodimers are expressed on NK cells and certain T cell subsets enabling the cells to recognize and respond to infected or transformed cells.
Biological function summary

NKG2C serves as an activating receptor for NK cells and certain T cells enhancing their cytotoxic functions. It participates in the recognition of cells expressing human cytomegalovirus (HCMV) proteins allowing the immune system to target and eliminate these infected cells efficiently. This receptor acts in a complex with DAP12 through which it transmits activation signals inside the immune cells. The engagement of NKG2C with its ligands initiates the production and release of cytokines and lytic granules promoting the destruction of target cells.

Pathways

NKG2C functions within the immune signaling pathways by interacting with other receptors and molecules on NK cells. The receptor is involved in pathways that activate NK cell-mediated cytotoxicity and cytokine production. NKG2C interacts with other natural killer receptors such as NKG2A and NKG2E contributing to the regulation of immune responses. The balance of signals from different receptors including NKG2C and NKG2A defines the activation and inhibition states of NK cells impacting both innate and adaptive immunity.

NKG2C expression has significance in viral infections and autoimmune diseases. In cases of viral infections like HCMV increased expression of NKG2C enhances the immune response against the virus by recognizing the virus-infected cells. In autoimmune disorders changes in NKG2C expression or function can alter immune regulation which may exacerbate disease conditions. NKG2C and its relationship with DAP12 as well as other immune receptors make it a valuable target for therapeutic interventions in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed : 30134159, PubMed : 37264229, PubMed : 9754572). Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed : 20952657, PubMed : 21825173). Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed : 15940674, PubMed : 9655483).
See full target information KLRC2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 51:10292-10308 PubMed37650637

2023

A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Lounis Yakhou,Anaelle Azogui,Nikhil Gupta,Julien Richard Albert,Fumihito Miura,Laure Ferry,Kosuke Yamaguchi,Sarah Battault,Pierre Therizols,Frédéric Bonhomme,Elouan Bethuel,Arpita Sarkar,Maxim V C Greenberg,Paola B Arimondo,Gael Cristofari,Olivier Kirsh,Takashi Ito,Pierre-Antoine Defossez
View all publications
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