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AB247146

Anti-NKG2E antibody

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(1 Publication)

Rabbit Polyclonal NKG2E antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KLRC3 aa 200 to C-terminus.

View Alternative Names

NKG2E, KLRC3, NKG2-E type II integral membrane protein, NK cell receptor E, NKG2-E-activating NK receptor

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NKG2E antibody (AB247146)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NKG2E antibody (AB247146)

Paraffin-embedded human tonsil tissue stained for NKG2E using ab247146 at 1/20 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KLRC3 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q07444

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NKG2E also known as KLRC3 is a protein involved in immune response regulation. It belongs to the killer cell lectin-like receptor subfamily K (NKG2) and has a predicted mass of approximately 25 kDa. NKG2E is primarily expressed on natural killer (NK) cells and some T cell subsets. This expression is important for these cells' ability to recognize and eliminate infected or malignant cells. NKG2E operates through interactions with other proteins and may form complexes to mediate immune signaling.
Biological function summary

NKG2E interacts with other components on cellular surfaces to play a role in activating immune cell responses. It often forms complexes with the adapter protein DAP12 which contains immunoreceptor tyrosine-based activation motifs (ITAMs). This interaction leads to the triggering of downstream signaling cascades upon recognition of stress-induced ligands on infected or tumor cells. The result is increased cytotoxicity and cytokine production which contribute to immune surveillance.

Pathways

NKG2E is significant in immune checkpoint pathways that regulate the balance between immune activation and tolerance. It is linked with the Natural Killer cell mediated cytotoxicity pathway and interacts with HLA class I ligands. NKG2E's association with other proteins such as NKG2D and CD94 exists within these pathways serving to modulate the activation threshold and function of NK cells and certain T cells therefore maintaining immune homeostasis.

NKG2E shows connections to cancer and viral infections where immune evasion mechanisms need counteracting. Tumor cells sometimes alter the expression of ligands that engage NKG2E influencing the effectiveness of NK cell surveillance. In viral infections NKG2E's role in recognizing stress-induced ligands supports defense against pathogens like cytomegalovirus (CMV). The protein's connection with the adapter protein DAP12 is instrumental in these immune responses and may highlight potential therapeutic strategies targeting immune modulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
See full target information KLRC3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:13811 PubMed40259011

2025

Human RCC1L is involved in the maintenance of mitochondrial nucleoids and mtDNA.

Applications

Unspecified application

Species

Unspecified reactive species

Emi Matsumoto,Taeko Sasaki,Tetsuya Higashiyama,Narie Sasaki
View all publications
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