Anti-NKIRAS1 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

NKIRAS1 is involved in the regulation of immune and inflammatory responses. It forms a part of the IκB complex which prevents the nuclear translocation of NF-κB a transcription factor that controls the expression of several genes related to immune response and cell survival. As a result NKIRAS1 plays a role in maintaining cellular homeostasis and preventing excessive inflammation. By modulating NF-κB signaling it can influence processes like cell proliferation apoptosis and cytokine production.

Pathways

NKIRAS1 functions within the NF-κB signaling pathway and interacts with the TGF-β pathway. In the NF-κB pathway NKIRAS1 connects with proteins like IKK (IκB kinase) and IκB to control the release and activity of NF-κB. In the TGF-β pathway interactions with SMAD proteins have been noted suggesting a role in regulating cell growth and differentiation. These pathways highlight NKIRAS1's importance in immune regulation and cell fate decisions.