Anti-NKR-P1C antibody [EPR22990-12]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NKR-P1C also known as NK1.1 is a C-type lectin-like receptor expressed on the surface of natural killer (NK) cells and some T cells. In mice this protein has a molecular mass of approximately 30 to 46 kDa. Researchers often focus on its distribution in cellular compartments which includes lymphoid tissues such as the spleen and thymus. This receptor is known for playing a role in the regulation of immune responses by enabling NK cells to recognize and eliminate target cells.

Biological function summary

NKR-P1C is critical in the activation and inhibition of natural killer cell functions. This protein does not operate alone but often functions as part of an immune receptor complex. It contributes to the balance between activating and inhibitory signals that determine NK cell responses. NKR-P1C can bind to ligands that influence the cytotoxic activity of these cells toward infected or malignant cells.

Pathways

NKR-P1C integrates into important immune signaling pathways such as the NK cell-mediated cytotoxicity pathway. This pathway involves interactions with other receptors like Ly49 and NKG2D which modulate NK cell activities. NKR-P1C plays an essential role in transmitting signals that lead to the release of cytokines and the destruction of afflicted cells coordinating with these receptors to execute immune functions.

Associated diseases and disorders

NKR-P1C has associations with cancer and viral infections where it influences NK cell interventions against pathologies. During tumor development or viral infection NKR-P1C may change expression patterns potentially affecting immune surveillance and responses. It works in tandem with proteins like perforin and granzymes which are involved in inducing cell death in target cells making it a significant player in immune responses to malignancies and persistent viruses.