AB174600

Anti-NKR-P1C antibody [PK136] - BSA and Azide free

Name: Anti-NKR-P1C antibody [PK136] - BSA and Azide free (ab174600) | Abcam
Brand: Abcam Limited
SKU: AB174600
Price: 905 USD
Availability: InStock

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(3 Publications)

Mouse Monoclonal NKR-P1C antibody. Carrier free. Suitable for Flow Cyt, FuncS and reacts with Mouse samples. Cited in 3 publications.

View Alternative Names

CD161c, Ly55c, Nkrp1c, Klrb1c, Killer cell lectin-like receptor subfamily B member 1C, CD161 antigen-like family member C, Lymphocyte antigen 55c, NK1.1, NKR-P1.9, NKR-P1C, Natural killer cell surface protein P1-40, Ly-55c, NKR-P1 40

519 FITC

FITC Anti-NKR-P1C antibody [PK136]
695 PerCP/Cy5.5®

PerCP/Cy5.5® Anti-NKR-P1C antibody [PK136]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

PK136

Isotype

IgG2a

Light chain type

kappa

Carrier free

Yes

Reacts with

Mouse

Applications

Flow Cyt, FuncS

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "FuncS" : {"fullname" : "Functional Studies", "shortname":"FuncS"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>(Final test volume = 100 uL). <a href='/en-us/products/primary-antibodies/mouse-igg2c-kappa-monoclonal-18c8bc7ad10-isotype-control-ab170191'>ab170191</a> - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>", "FuncS-species-checked": "guaranteed", "FuncS-species-dilution-info": "", "FuncS-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification

Purification notes

Purified from tissue culture supernatant

Storage buffer

pH: 7.2 Constituents: 0.87% Sodium chloride, 0.14% Sodium dihydrogen phosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NKR-P1C also known as NK1.1 is a C-type lectin-like receptor expressed on the surface of natural killer (NK) cells and some T cells. In mice this protein has a molecular mass of approximately 30 to 46 kDa. Researchers often focus on its distribution in cellular compartments which includes lymphoid tissues such as the spleen and thymus. This receptor is known for playing a role in the regulation of immune responses by enabling NK cells to recognize and eliminate target cells.

Biological function summary

NKR-P1C is critical in the activation and inhibition of natural killer cell functions. This protein does not operate alone but often functions as part of an immune receptor complex. It contributes to the balance between activating and inhibitory signals that determine NK cell responses. NKR-P1C can bind to ligands that influence the cytotoxic activity of these cells toward infected or malignant cells.

Pathways

NKR-P1C integrates into important immune signaling pathways such as the NK cell-mediated cytotoxicity pathway. This pathway involves interactions with other receptors like Ly49 and NKG2D which modulate NK cell activities. NKR-P1C plays an essential role in transmitting signals that lead to the release of cytokines and the destruction of afflicted cells coordinating with these receptors to execute immune functions.

NKR-P1C has associations with cancer and viral infections where it influences NK cell interventions against pathologies. During tumor development or viral infection NKR-P1C may change expression patterns potentially affecting immune surveillance and responses. It works in tandem with proteins like perforin and granzymes which are involved in inducing cell death in target cells making it a significant player in immune responses to malignancies and persistent viruses.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.

See full target information Klrb1c

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Molecular oncology 14:2436-2454 PubMed32797726

2020

In vivo anti-V-ATPase antibody treatment delays ovarian tumor growth by increasing antitumor immune responses.

Applications

Unspecified application

Species

Unspecified reactive species

Arpita Kulshrestha,Gajendra K Katara,Safaa A Ibrahim,Valerie E Riehl,Sylvia Schneiderman,Mahmood Bilal,Alexandria N Young,Shayna Levine,Sara Fleetwood,James Dolan,Alice Gilman-Sachs,Kenneth D Beaman

Cell death and differentiation 27:1383-1397 PubMed31562368

2019

RBX1 prompts degradation of EXO1 to limit the homologous recombination pathway of DNA double-strand break repair in G1 phase.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Xie,Yi-Ke Liu,Zong-Pei Guo,Hua Guan,Xiao-Dan Liu,Da-Fei Xie,Yi-Guo Jiang,Teng Ma,Ping-Kun Zhou

Frontiers in immunology 9:3038 PubMed30728823

2019

Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Manu Chhabra,Jawaher Alsughayyir,M Saeed Qureshi,Mekhola Mallik,Jason M Ali,Ivonne Gamper,Ellen L Moseley,Sarah Peacock,Vasilis Kosmoliaptsis,Martin J Goddard,Michelle A Linterman,Reza Motallebzadeh,Gavin J Pettigrew

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-NKR-P1C antibody [PK136] - BSA and Azide free

Related conjugates and formulations (2)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

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Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise