Anti-Nkx2.4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Nkx2.4 also known as a homeobox protein Nkx-2.4 is a transcription factor that influences gene expression important for developmental processes. This protein has a molecular mass of approximately 29 kDa. Nkx2.4 expression occurs mainly in the developing neural tissues and some other tissues during embryogenesis. Researchers find it critical in the patterning and differentiation of these tissues often interacting with DNA sequences to regulate specific gene expression.

Biological function summary

Nkx2.4 contributes to neural differentiation and development. It acts independently or in conjunction with other proteins as part of larger transcriptional complexes. These complexes ensure proper progression in developmental processes as Nkx2.4 guides target gene expression during early development. Its involvement is linked to controlling the formation of various neural structures demonstrating its fundamental role in embryonic development.

Pathways

Nkx2.4 is important in the formation and differentiation within the Wnt signaling and Notch pathways. It collaborates with other proteins like Sox2 and Pax6 performing specific roles that aid in defining the development of neural cells. Nkx2.4 regulates genes situating early in these pathways guiding cell-fate decisions and structural development during embryogenesis.

Associated diseases and disorders

Nkx2.4's malfunction links to neurological disorders and developmental abnormalities. Misregulation or mutations in Nkx2.4 have associations with certain congenital conditions affecting the neural system. It also interacts with proteins such as Lhx3 in disease contexts emphasizing the need for proper Nkx2.4 function to ensure typical neural development and maintain health.