Rabbit Polyclonal NLRC5 antibody. Suitable for WB and reacts with Mouse samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Human NLRC5.
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- International journal of molecular sciences 24:2023NLRC5 Deficiency Reduces LPS-Induced Microglial Activation via Inhibition of NF-κB Signaling and Ameliorates Mice's Depressive-like Behavior.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChen Sun,Yuqing Shen,Piaopiao Liu,Yi Shen,Yue Hu,Ping Li,Ying Zhang,Fengqin Miao,Jianqiong ZhangPubMed 37686068
- Autophagy 19:1332-13472022NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiawei Hao,Jinqian Li,Zhenzhen Zhang,Yang Yang,Qing Zhou,Tiantian Wu,Tongling Chen,Zhongdao Wu,Ping Zhang,Jun Cui,Yi-Ping LiPubMed 36126167
- Technology in cancer research & treatment 21:153303382211127422022NLRC5 Might Promote Endometrial Cancer Progression by Inducing PD-L1 Expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSu-Ding Zhu,Jing Zhang,Xiao-Jing Liu,Jun-Hui Zhang,Bing Wei,Wen-Yan Wang,Yi-Jun Fan,Dan Li,Yun-Xia Cao,Lei ZhanPubMed 35880269
- Frontiers in cell and developmental biology 9:6696962021The Regulatory NOD-Like Receptor NLRC5 Promotes Ganglion Cell Death in Ischemic Retinopathy by Inducing Microglial Pyroptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYang Deng,Yunzhao Fu,Longxiang Sheng,Yixin Hu,Lishi Su,Jiawen Luo,Chun Yan,Wei ChiPubMed 34095138
- Frontiers in pharmacology 11:12812020NLRC5 Inhibits Inflammation of Secretory Phase Ectopic Endometrial Stromal Cells by Up-Regulating Autophagy in Ovarian Endometriosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRunhua He et. al.PubMed 33013364
- The Journal of international medical research 48:3000605209404552020NLRC5 alleviated OGD/R-induced PC12-cell injury by inhibiting activation of the TLR4/MyD88/NF-κB pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhen Zhang,Yuhan Sun,Xin ChenPubMed 32790491
- HLA 96:197-2012020Human-porcine MHC-I homology allows for antibody cross-reactivity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNicole Forneris,Heather Levy,Christopher BurlakPubMed 32452158
- Biochemical and biophysical research communication 528:545-5532020NLRC5 deficiency ameliorates cardiac fibrosis in diabetic cardiomyopathy by regulating EndMT through Smad2/3 signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBo Wang et. al.PubMed 32505342
- The Journal of international medical research 48:3000605209253522020NLRC5 promotes cell migration and invasion by activating the PI3K/AKT signaling pathway in endometrial cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYijun Fan,Zhen Dong,Yuchuan Shi,Shiying Sun,Bing Wei,Lei ZhanPubMed 32431202
- Translational cancer research 9:2609-26172020NLRC5, a valuable marker for the diagnosis and prognostic assessment of hepatocellular carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiu-Wen Zhang,Run-Da Wu,Huan Wang,Fei Hu,Zhong-Qi MaoPubMed 35117620
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human NLRC5. The exact immunogen used to generate this antibody is proprietary information. Database link Q86WI3
Reactivity data
Select an application| WB | |
|---|---|
| Mouse | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1.00000-2.00000 µg/mL | Notes - |
Target data
Function
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
Alternative names
NOD27, NOD4, NLRC5, Protein NLRC5, Caterpiller protein 16.1, Nucleotide-binding oligomerization domain protein 27, Nucleotide-binding oligomerization domain protein 4, CLR16.1
Recommended products
Rabbit Polyclonal NLRC5 antibody. Suitable for WB and reacts with Mouse samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Human NLRC5.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human NLRC5. The exact immunogen used to generate this antibody is proprietary information. Database link Q86WI3
- Purification technique
- Affinity purification Immunogen
- Specificity
ab105411 is predicted to not cross react with other NLRP family members.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NLRC5 also known as NOD-like receptor family CARD domain-containing 5 is an important protein in the immune response. It has a molecular mass of approximately 186 kDa. This protein locates primarily in the cytoplasm of cells with high expression levels in immune tissues such as the spleen and lymph nodes. Mechanically NLRC5 acts as a transcriptional regulator controlling the expression of major histocompatibility complex (MHC) class I genes. This function plays a critical role in the immune system by facilitating the presentation of endogenous antigens.
- Biological function summary
NLRC5 engages in enhancing immune surveillance and antiviral responses by regulating MHC class I transcription. It acts as part of the larger NLR family of proteins which are known to participate in the immune system's response to pathogens. In addition to its role in the immune response NLRC5 can interact with components of the inflammasome complex although its presence in the inflammasome remains controversial. These mechanisms are essential in initializing and sustaining an immune response against infections.
- Pathways
NLRC5 involves itself in the interferon signaling pathway and antigen processing and presentation pathways. In the context of interferon signaling NLRC5 influences the activation of genes that drive antiviral states by interacting with proteins such as IRF1 and STAT1. This regulatory role positions NLRC5 as a bridge between innate and adaptive immune responses ensuring proper signaling and presentation of antigens to T cells for effective immune resolution.
- Associated diseases and disorders
NLRC5 exhibits alterations in conditions such as some auto-inflammatory disorders and cancer. Deregulation of NLRC5 can contribute to diseases like systemic lupus erythematosus where its altered expression affects immune function and tolerance. In certain cancers such as hepatocellular carcinoma NLRC5 interacts with oncogenic pathways influencing tumor growth and immune evasion. Researchers explore connections between NLRC5 and proteins like MHC class I molecules to understand their roles in disease mechanisms and therapeutic potentials.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-NLRC5 antibody (ab105411)
All lanes: Western blot - Anti-NLRC5 antibody (ab105411) at 1 µg/mL
All lanes: EL4 cell lysate
Predicted band size: 204 kDa
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