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Rabbit Polyclonal NLRP10 antibody. N-terminal. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human NLRP10.

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Images

Western blot - Anti-NLRP10 antibody - N-terminal (AB198810), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human NLRP10. The exact immunogen used to generate this antibody is proprietary information. Database link Q86W26

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Mouse
Tested

Tested
Tested

Species

Mouse

Dilution info

1/500.00000 - 1/2000.00000

Notes

-

Associated Products

Select an associated product type

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Target data

Function

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819).

Alternative names

Recommended products

Rabbit Polyclonal NLRP10 antibody. N-terminal. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human NLRP10.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human NLRP10. The exact immunogen used to generate this antibody is proprietary information. Database link Q86W26
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The NLRP10 protein also known as NALP10 or PYNOD plays a significant role in the immune system. NLRP10 has a molecular mass of approximately 81 kDa and belongs to the nucleotide-binding domain leucine-rich repeat (NLR) family. It is expressed predominantly in immune cells such as macrophages and dendritic cells. Structurally NLRP10 lacks the pyrin domain that is common to other members of its family which influences its function.

Biological function summary

NLRP10 modulates inflammatory responses and immune cell activity. It functions as part of the innate immune system and is linked to the regulation of inflammasomes. NLRP10 is also connected with dendritic cell migration influencing the immune response to pathogens. By controlling cytokine release it plays a role in mitigating excessive inflammation.

Pathways

NLRP10 integrates into the inflammatory signaling processes. It impacts the NF-κB signaling pathway an important regulator of immune response. Where the pathway involves inflammasomes NLRP10 interacts with other NLR family members like NLRP3. These interactions modulate immune responses through complex pathways affecting how cells respond to infections.

Associated diseases and disorders

NLRP10 is linked to autoimmune conditions and allergies. In autoimmune diseases such as lupus the regulatory role of NLRP10 influences the immune system’s tolerance to self-antigens. In allergic conditions it modulates the inflammatory response and cytokine release. There are connections with proteins like NLRP3 in these disorders where both play roles in the immune system's regulation and inflammation control.

Product promise

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1 product image

  • Western blot - Anti-NLRP10 antibody - N-terminal (ab198810), expandable thumbnail

    Western blot - Anti-NLRP10 antibody - N-terminal (ab198810)

    Gel: 8%SDS-PAGE

    All lanes: Western blot - Anti-NLRP10 antibody - N-terminal (ab198810) at 1/300 dilution

    Lane 1: mouse heart tissue lysate at 40 µg

    Lane 2: mouse skeletal muscle tissue lysate at 40 µg

    Predicted band size: 75 kDa

    Exposure time: 1min

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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