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AB105408

Anti-NLRP11 antibody

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(2 Publications)

Rabbit Polyclonal NLRP11 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NLRP11.

View Alternative Names

NALP11, NOD17, PAN10, PYPAF6, NLRP11, Nucleotide-binding oligomerization domain protein 17, PAAD-and NACHT domain-containing protein 10, PYRIN-containing APAF1-like protein 6

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-NLRP11 antibody (AB105408)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NLRP11 antibody (AB105408)

Immunocytochemistry of HeLa cells with ab105408 at 2.5 μg/mL.

Immunocytochemistry/ Immunofluorescence - Anti-NLRP11 antibody (AB105408)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-NLRP11 antibody (AB105408)

Immunofluorescence of NLRP11 in HeLa cells with ab105407 at 20 ug/mL.

Western blot - Anti-NLRP11 antibody (AB105408)
  • WB

Unknown

Western blot - Anti-NLRP11 antibody (AB105408)

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Western blot - Anti-NLRP11 antibody (ab105408) at 1 µg/mL

All lanes:

HeLa cell lysate at 15 µg

Predicted band size: 117 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human NLRP11. The exact immunogen used to generate this antibody is proprietary information.

P59045

Specificity

At least three isoforms of NLRP11 are known to exist; this antibody will recognize all of them. NLRP11 antibody is predicted to not cross-react with other NLRP family members

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NLRP11 also known as NALP11 is part of the NOD-like receptor (NLR) family which includes proteins involved in immune system regulation. It weighs approximately 116 kDa. This protein is expressed in the cytoplasm of various tissues with higher levels detected in reproductive tissues such as the ovaries and in immune-related tissues. NLRP11 has a tripartite structure comprising a PYD domain a NACHT domain and leucine-rich repeats which enables it to participate in protein-protein interactions.
Biological function summary

NLRP11 engages in innate immune responses by modulating inflammatory signaling pathways. It is part of the inflammasome complex although its exact role within this complex is less understood compared to more studied members like NLRP3. NLRP11 may also influence cytokine release contributing to the body's defense against pathogens. The tissue-specific expression indicates its possible role in reproductive immunology and local inflammation.

Pathways

NLRP11 lies within the inflammasome pathway and is indirectly linked to the NF-kB signaling pathway. Within these it intersects with proteins such as ASC (Apoptosis-associated Speck-like protein containing a CARD) and caspase-1 highlighting its involvement in the regulation of inflammatory processes. The exact interactions within these pathways remain an active area of research but they suggest a potential regulatory role in cellular inflammation response.

NLRP11 has been tentatively connected to inflammatory and autoimmune conditions. Some studies suggest a possible involvement in conditions like systemic lupus erythematosus (SLE) due to its influence on cytokine regulation and inflammation. Moreover disruptions in its expression or function may relate to irregular immune responses in reproductive disorders. Further study is needed but NLRP11 shares connections with NLRP3 and other inflammasome components that are more firmly linked to such diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in inflammation.
See full target information NLRP11
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 8:125 PubMed39865169

2025

NLRP7 maintains the genomic stability during early human embryogenesis via mediating alternative splicing.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongliang Chen,Liangxia Jiang,Min Su,Qibing Zeng,Peng Luo,Liangzhao Chu

Nature immunology 23:892-903 PubMed35624206

2022

NLRP3 licenses NLRP11 for inflammasome activation in human macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Anu Gangopadhyay,Savita Devi,Shivendra Tenguria,Jessica Carriere,Huyen Nguyen,Elisabeth Jäger,Hemisha Khatri,Lan H Chu,Rojo A Ratsimandresy,Andrea Dorfleutner,Christian Stehlik
View all publications
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Product promise

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