Anti-NLRP13 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

NOD-like receptors such as NLRP13 participate in the formation of inflammasomes which are multiprotein complexes that activate inflammatory responses. NLRP13 functions as a sensor that detects specific signals and associates with other proteins to assemble the inflammasome. This assembly leads to the activation of caspases particularly caspase-1 which then cleaves pro-inflammatory cytokines like IL-1β resulting in their active forms. These cytokines are important for mounting effective immune responses against infections.

Pathways

NLRP13 plays a role in the innate immune signaling pathways specifically in the inflammasome pathway. This pathway is essential for detecting pathogens and initiating early immune responses. NLRP13 interacts with other NOD-like receptors and inflammasome components such as ASC (Apoptosis-associated speck-like protein containing a CARD) to propagate these immune signals. This orchestration leads to the appropriate inflammatory response needed to control infections.