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AB105405

Anti-NLRP7 antibody

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(2 Publications)

Rabbit Polyclonal NLRP7 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NLRP7.

View Alternative Names

NALP7, NOD12, PYPAF3, NLRP7, Nucleotide-binding oligomerization domain protein 12, PYRIN-containing APAF1-like protein 3

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NLRP7 antibody (AB105405)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NLRP7 antibody (AB105405)

Immunohistochemistry of Human brain tissue with ab105405 at 10 μg/mL.

Immunocytochemistry/ Immunofluorescence - Anti-NLRP7 antibody (AB105405)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-NLRP7 antibody (AB105405)

Immunofluorescence of NLRP7 in Human brain tissue with ab105405 at 20 ug/mL.

Western blot - Anti-NLRP7 antibody (AB105405)
  • WB

Supplier Data

Western blot - Anti-NLRP7 antibody (AB105405)

All lanes:

Western blot - Anti-NLRP7 antibody (ab105405) at 2 µg/mL

Lane 1:

K562 cell lysate

Lane 2:

K562 cell lysate with Blocking peptide

Predicted band size: 111 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human NLRP7. The exact immunogen used to generate this antibody is proprietary information.

Q8WX94

Specificity

At least four isoforms of NLRP7 are known to exist; this antibody will recognize all of them. This antibody is predicted to not cross-react with other NLRP family members.

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NLRP7 also known as NALP7 is a protein involved in immune response signaling. It has a molecular mass of approximately 103 kDa. Scientists have found that NLRP7 is expressed predominantly in reproductive tissues. It belongs to the NOD-like receptor (NLR) family specifically characterized by its role in detecting intracellular pathogens and stress signals. Structurally NLRP7 contains an N-terminal pyrin domain a central nucleotide-binding domain and C-terminal leucine-rich repeats which are essential for its function in pathogen recognition and activation of inflammatory responses.
Biological function summary

This protein plays a significant role in the regulation of inflammation and has been implicated in the formation of inflammasomes. NLRP7 can assemble into multiprotein complexes known as inflammasomes which serve as platforms for the activation of caspase-1 a protease critical for the maturation and secretion of pro-inflammatory cytokines such as IL-1β and IL-18. Additionally researchers recognize the involvement of NLRP7 in reproductive processes where its dysregulation may affect fertility.

Pathways

NLRP7 is notably involved in the inflammatory signaling pathways. It interacts with other inflammasome-related proteins like ASC and caspase-1 to mediate innate immune responses. The assembly and activation of inflammasomes by NLRP7 play a significant role in the immune system's ability to respond to cellular damage and infectious agents. The interaction with ASC leads to the formation of a complex that facilitates the enzymatic cleavage and activation of pro-caspase-1 further propagating the inflammatory cascade.

Scientists have associated NLRP7 predominantly with recurrent hydatidiform moles a gestational trophoblastic disorder. This abnormal growth of trophoblasts the cells that normally develop into the placenta links to mutations in the NLRP7 gene leading to impaired inflammatory signaling. Additionally variations in NLRP7 have connections with immune-related disorders due to its role in regulatory pathways of innate immunity. These disorders often manifest in the reproductive system because of NLRP7’s tissue-specific expression and function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits CASP1/caspase-1-dependent IL1B secretion.
See full target information NLRP7
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 8:125 PubMed39865169

2025

NLRP7 maintains the genomic stability during early human embryogenesis via mediating alternative splicing.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongliang Chen,Liangxia Jiang,Min Su,Qibing Zeng,Peng Luo,Liangzhao Chu

Nature communications 8:15203 PubMed28492230

2017

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity.

Applications

WB, Fluorescence Microscopy

Species

Human, Human

Joseph S Bednash,Nathaniel Weathington,James Londino,Mauricio Rojas,Dexter L Gulick,Robert Fort,SeungHye Han,Alison C McKelvey,Bill B Chen,Rama K Mallampalli
View all publications
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