Rabbit Polyclonal NMDAR1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human GRIN1 aa 800 to C-terminus.
Images
Publications
Filter by
- Cells 12:2023The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRafael Rivas-Santisteban,Iu Raïch,David Aguinaga,Carlos A Saura,Rafael Franco,Gemma NavarroPubMed 36672218
- Neurochemical research 48:791-8032022Munc18-1 Contributes to Hippocampal Injury in Septic Rats Through Regulation of Syntanxin1A and Synaptophysin and Glutamate Levels.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFajuan Tang,Lin Chen,Hu Gao,Yupeng Lei,Linli Pan,Dongqiong Xiao,Xihong LiPubMed 36335177
- International journal of molecular sciences 22:2021Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnna Tyrtyshnaia,Anatoly Bondar,Sophia Konovalova,Igor ManzhuloPubMed 34884587
- Brain sciences 11:2021Modulation of Hippocampal Astroglial Activity by Synaptamide in Rats with Neuropathic Pain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIgor Manzhulo,Olga Manzhulo,Anna Tyrtyshnaia,Arina Ponomarenko,Sophia Konovalova,Ekaterina Ermolenko,Elena Milkina,Anna StarinetsPubMed 34942863
- Alzheimer's research & therapy 13:1842021N-Methyl-D-aspartate (NMDA) and cannabinoid CB receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRafael Rivas-Santisteban,Alejandro Lillo,Jaume Lillo,Joan-Biel Rebassa,Joan S Contestí,Carlos A Saura,Rafael Franco,Gemma NavarroPubMed 34749800
- Disease markers 2021:99903822021Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Ovarian Teratoma in South China-Clinical Features, Treatment, Immunopathology, and Surgical Outcomes of 21 Cases.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHuiyun Jiang,Huixia Ye,Yifeng Wang,Yunhui Li,Ying Wang,Xiaomao LiPubMed 34093900
- Experimental brain research 239:2015-20242021Increased immunoreactivity of glutamate receptors, neuronal nuclear protein and glial fibrillary acidic protein in the hippocampus of epileptic rats with fast ripple activity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGustavo A Chiprés-Tinajero,Miguel A Núñez-Ochoa,Laura Medina-CejaPubMed 33909110
- Frontiers in psychiatry 11:5152020Effect of Jian-Pi-Zhi-Dong Decoction on the Amino Acid Neurotransmitters in a Rat Model of Tourette Syndrome and Comorbid Anxiety Disorder.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWen Zhang et. al.PubMed 32581885
- Behavioural brain research 390:1126592020Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSara R Westbrook et. al.PubMed 32437887
- Brain and behavior 10:e015762020Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarjan Hosseini et. al.PubMed 32189472
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human GRIN1 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q05586
Consider this alternative
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/1000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Associated Products
Select an associated product type
5 products for Alternative Product
Target data
Function
Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:7679115, PubMed:7681588, PubMed:7685113). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (PubMed:26875626). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:27164704, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:38538865, PubMed:7679115, PubMed:7681588, PubMed:7685113). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761, PubMed:36309015, PubMed:38598639).
Alternative names
NMDAR1, GRIN1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, hNR1
Recommended products
Rabbit Polyclonal NMDAR1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human GRIN1 aa 800 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human GRIN1 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q05586
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NMDAR1 also known as GluN1 is a subunit of the NMDA receptor a type of ion channel protein found in the brain. This receptor weighs around 120 kDa and plays an important role in synaptic transmission and plasticity. NMDAR1 operates as part of a receptor complex that allows for calcium influx when activated. It shows high expression throughout the central nervous system primarily in neurons across the cortex and hippocampus. The receptor's function is important to certain calcium-dependent processes in the brain.
- Biological function summary
NMDA receptors including the NMDAR1 subunit serve essential functions in synaptic plasticity and memory processes. As part of the receptor complex NMDAR1 contributes to the control of synaptic strength. It requires co-activation by glutamate and glycine or D-serine linking its function to excitatory neurotransmission. The receptor's capacity to modulate synaptic connections forms the basis of learning and long-term memory.
- Pathways
NMDAR1 plays a critical role in the glutamatergic pathway influencing synaptic plasticity and memory function. It interacts with other proteins like PSD-95 within the postsynaptic density. NMDAR1 is also involved in the calcium signaling pathway due to its ability to facilitate calcium entry into neurons upon synaptic activity. This positions the receptor as an important modulator in pathways that control neuronal communication and plasticity.
- Associated diseases and disorders
NMDA receptor dysfunction including the NMDAR1 subunit links to neurodegenerative diseases such as Alzheimer's. The alterations in NMDAR1 function can lead to excitotoxicity contributing to neuronal damage. NMDAR1 also associates with schizophrenia where altered glutamatergic transmission has been observed. Here abnormalities in proteins like the synaptic scaffolding protein PSD-95 have also been noted to relate to NMDAR1 dysfunction in the pathophysiology of these disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Western blot - Anti-NMDAR1 antibody - Neuronal Marker (ab52177)
NMDAR1 Western blot staining using rabbit Anti-NMDAR1 antibody
All lanes: Western blot - Anti-NMDAR1 antibody - Neuronal Marker (ab52177) at 1/500 dilution
Lane 1: A549 (Human lung adenocarcinoma epithelial cell line) whole cell lysate at 10 µg
Lane 2: Y79 (Human retinoblastoma cell line) whole cell lysate at 10 µg
Lane 3: Raji (Human Burkitt's lymphoma cell line) whole cell lysate at 10 µg
SecondaryAll lanes: Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
Predicted band size: 105 kDa
Observed band size: 30 kDa, 75 kDa, 95 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMDAR1 antibody (ab52177)
ab52177 at 1/50 dilution staining NMDAR1 in human brain tissue by immunohistochemistry (paraffin embedded tissue) in the presence (right image) or absence (left image) of the immunizing peptide.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com