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AB272562

Anti-NMES1 antibody

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Rabbit Polyclonal NMES1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human NMES1 aa 1 to C-terminus.

View Alternative Names

C15orf48, NMES1, Normal mucosa of esophagus-specific gene 1 protein, Protein FOAP-11

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMES1 antibody (AB272562)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMES1 antibody (AB272562)

Paraffin-embedded formalin-fixed Human colon tissue stained for NMES1 using ab272562 at 1/200 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMES1 antibody (AB272562)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMES1 antibody (AB272562)

Paraffin-embedded formalin-fixed Human liver tissue stained for NMES1 using ab272562 at 1/200 in immunohistochemical analysis. No positivity in hepatocytes as expected.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMES1 antibody (AB272562)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMES1 antibody (AB272562)

Paraffin-embedded formalin-fixed Human rectum tissue stained for NMES1 using ab272562 at 1/200 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMES1 antibody (AB272562)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMES1 antibody (AB272562)

Paraffin-embedded formalin-fixed Human pancreas tissue stained for NMES1 using ab272562 at 1/200 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMES1 antibody (AB272562)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMES1 antibody (AB272562)

Paraffin-embedded formalin-fixed Human testis tissue stained for NMES1 using ab272562 at 1/200 in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human NMES1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9C002

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NMES1 also known as NMES1-1 is a protein involved in cellular organization and structural stability. The protein has a molecular mass of approximately 10 kDa and is primarily expressed in muscle tissues particularly in the skeletal muscle. Research shows NMES1's expression in some smooth muscle tissues as well. It has a distinct role in influencing the cellular scaffold due to its ability to interact with cytoskeletal elements. Although research on NMES1 is still developing its interactions suggest a function in maintaining cellular integrity.
Biological function summary

NMES1 influences cellular structure and organization. While it does not typically exist as part of large protein complexes its role in cytoskeletal interactions places it at the core of cellular stability mechanisms. NMES1 interacts with microtubules and actin filaments underpinning the cellular framework essential for muscle contraction and mechanical stress response. These interactions highlight its potential role in cellular processes beyond simple structural support.

Pathways

NMES1 involvement centers on cytoskeletal regulation and muscle contraction processes. It plays a part in the actin cytoskeleton signaling pathway where it interacts with proteins like actin-binding molecules that modulate cellular tension and motility. Additionally NMES1 has connections with muscle-specific signaling pathways like the myogenesis pathway suggesting its participation in muscle cell differentiation and growth. Through these interactions it supports the integration of mechanical signals into biological responses.

NMES1 has implications in muscular dystrophy and muscle degeneration disorders. Dysfunction or abnormal expression of NMES1 can disrupt cellular organization leading to weakened muscle fibers and loss of muscle function. The protein interacts with dystrophin which is a critical component in maintaining muscle cell integrity. Alterations in NMES1 expression or function can exacerbate disease phenotypes emphasizing its potential therapeutic significance in muscle-related conditions.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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