JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB222893

Anti-NMNAT2 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal NMNAT2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NMNAT2 aa 1 to C-terminus.

View Alternative Names

C1orf15, KIAA0479, NMNAT2, Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2, NMN/NaMN adenylyltransferase 2, Nicotinamide mononucleotide adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NMN adenylyltransferase 2, NaMN adenylyltransferase 2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMNAT2 antibody (AB222893)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMNAT2 antibody (AB222893)

Paraffin-embedded human ovarian cancer tissue stained for NMNAT2 using ab222893 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human NMNAT2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BZQ4

style
left-column

Alternative Products

Primary Antibodies

AB56980

Anti-NMNAT2 antibody [2E4]

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-NMNAT2 antibody [2E4] (AB56980)

  • 4
  • 1

Complementary Products

Primary Antibodies

AB71904

Anti-NMNAT3 antibody

Western blot - Anti-NMNAT3 antibody (AB71904)

  • 0
  • 0
Primary Antibodies

AB118270

Anti-Nmnat1/NMNAT antibody [OTI1F7]

Immunocytochemistry/ Immunofluorescence - Anti-Nmnat1/NMNAT antibody [OTI1F7] (AB118270)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB191385

Anti-SIRT6 antibody [EPR18463]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-SIRT6 antibody [EPR18463] (AB191385)

  • 5
  • 2
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NMNAT2 (nicotinamide nucleotide adenylyltransferase 2) is an enzyme that plays a role in the biosynthesis of NAD+ by converting nicotinamide mononucleotide (NMN) and ATP to NAD+ and pyrophosphate. It is also known in some contexts as NAD+ synthetase isoform 2. The molar mass of NMNAT2 is about 33 kDa. NMNAT2 expression occurs predominantly in the brain and nervous tissues where it contributes to cellular energy homeostasis and metabolism.
Biological function summary

NMNAT2 serves essential roles in maintaining NAD+ levels which are critical for numerous enzymatic processes within the cell including metabolism and cellular repair. This protein is not typically found as part of a larger complex but interacts with various cell compartments especially in neurons. NMNAT2 has been identified as an important player in axon maintenance and survival and it can protect against injury-induced degeneration.

Pathways

NMNAT2 is essential in the NAD+ biosynthesis pathway. It interfaces with several cellular functions tied to energy metabolism and repair processes. It often works alongside other related enzymes such as NAMPT (nicotinamide phosphoribosyltransferase) supporting the conversion of precursors into NAD+. NMNAT2 contributes to maintaining adequate energy levels within cells linking it closely with mitochondrial health and function.

NMNAT2 is implicated in neurodegenerative conditions such as Alzheimer's disease and axonopathy. Its role in the nervous system relates to the prevention of axonal degeneration making it an important focus for research into potential therapeutic targets. Reduced NMNAT2 activity has been linked with elevated risk of neuronal damage and degeneration where its interaction with proteins like tau known for their association with Alzheimer's pathogenesis is significant.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Axon survival factor required for the maintenance of healthy axons : acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed : 16118205, PubMed : 17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed : 16118205, PubMed : 17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed : 16118205, PubMed : 17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed : 16118205, PubMed : 17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed : 16118205, PubMed : 17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed : 16118205, PubMed : 17402747). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (PubMed : 34314702). May be involved in the maintenance of axonal integrity (By similarity).
See full target information NMNAT2
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 6: PubMed36604149

2023

SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.

Applications

Unspecified application

Species

Unspecified reactive species

Akihiro Ikenaka,Yohko Kitagawa,Michiko Yoshida,Chuang-Yu Lin,Akira Niwa,Tatsutoshi Nakahata,Megumu K Saito
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com