AB229635

Anti-NMU antibody

Name: Anti-NMU antibody (ab229635) | Abcam
Brand: Abcam Limited
SKU: AB229635
Price: 525 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal NMU antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NMU.

View Alternative Names

Neuromedin-U, NMU

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMU antibody (AB229635)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMU antibody (AB229635)

Paraffin-embedded human small intestine tissue stained for NMU with ab229635 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMU antibody (AB229635)

Paraffin-embedded human colon cancer tissue stained for NMU with ab229635 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-NMU antibody (AB229635)

All lanes:

Western blot - Anti-NMU antibody (ab229635) at 1/1000 dilution

All lanes:

Mouse stomach tissue lysate

Secondary

All lanes:

Goat anti-Rabbit at 1/10000 dilution

Predicted band size: 20 kDa

Observed band size: 20 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NMU.

P48645

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuromedin U (NMU) is a regulatory peptide known for its role in modulating smooth muscle contraction and energy homeostasis. Alternate names include neuromedin reflecting its original discovery in the spinal cord. NMU has a molecular mass ranging between 2392 and 2583 Da depending on the variant. It is expressed predominantly in the gastrointestinal tract and central nervous system influencing various physiological processes within these tissues.

Biological function summary

NMU functions significantly within the nervous and endocrine systems. It is an important part of the larger neuromedin peptide family. NMU interacts with specific receptors NMU-R1 and NMU-R2 to mediate biological effects. Within the body NMU influences feeding behavior circadian rhythms and stress response mechanisms demonstrating its integral role in maintaining physiological balance.

Pathways

NMU integrates into hormonal and neuroendocrine signaling routes. The peptide participates in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis influencing stress responses. Its action also intersects the energy metabolism pathway interacting with proteins such as ghrelin and leptin. These interactions position NMU as an important player in energy intake control and stress regulation.

NMU has implications in obesity and inflammatory diseases. Abnormally high or low levels can contribute to metabolic disorders indicating its central role in energy balance and metabolic health. NMU's connection to the HPA axis associates it with proteins like corticotropin-releasing hormone which impacts inflammatory processes. Exploring NMU's involvement could unveil new therapeutic strategies for managing these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Neuromedin-U-25. Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.. Neuromedin precursor-related peptide 33. Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.. Neuromedin precursor-related peptide 36. Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.

See full target information NMU

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 12:763480 PubMed36110943

2022

La protein regulates protein expression by binding with the mRNAs of target genes and participates the pathological process of ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xuan Huang,Jialei Zhu,Yueyan Li,Yang Yu,Jing Tang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-NMU antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMU antibody (AB229635)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMU antibody (AB229635)

Western blot - Anti-NMU antibody (AB229635)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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