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AB198171

Anti-NOC2L antibody

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(2 Publications)

Rabbit Polyclonal NOC2L antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NOC2L.

View Alternative Names

NIR, NOC2L, Nucleolar complex protein 2 homolog, Protein NOC2 homolog, NOC2-like protein, Novel INHAT repressor

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOC2L antibody (AB198171)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOC2L antibody (AB198171)

Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue labeling NOC2L with ab198171 at a 1/20 dilution.

Western blot - Anti-NOC2L antibody (AB198171)
  • WB

Supplier Data

Western blot - Anti-NOC2L antibody (AB198171)

Gel : 6%SDS-PAGE

All lanes:

Western blot - Anti-NOC2L antibody (ab198171) at 1/200 dilution

All lanes:

HeLa cell lysate at 40 µg

Predicted band size: 85 kDa

true

Exposure time: 5s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human NOC2L. The exact immunogen used to generate this antibody is proprietary information.

Q9Y3T9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NOC2L also known as Nucleus accumbens-associated protein 1 is a protein that plays a mechanical role in modulating nuclear functions. It has a molecular weight of approximately 107 kDa. NOC2L is expressed in various tissues including human central nervous tissues and several others related to developmental processes. This protein interacts with chromatin and affects gene expression suggesting its influence on cellular function and growth regulation.
Biological function summary

NOC2L controls activities related to transcription regulation. It does not appear to form a large multi-protein complex but works alongside other nuclear proteins. By repressing the transcription of specific gene sets NOC2L plays a role in cellular homeostasis and differentiation. It influences key developmental stages and cellular responses to external stimuli.

Pathways

NOC2L integrates into transcriptional regulatory networks. It is actively involved in the p53 signaling pathway which contributes to cellular responses to stress and DNA repair mechanisms. NOC2L interacts with proteins like MDM2 which are important in this signaling cascade. Additionally NOC2L influences pathways that pertain to chromatin modification reflecting its role in gene regulation.

NOC2L has links to cancer and developmental disorders. Aberrations in its expression or function have been associated with tumorigenesis likely due to its involvement in the p53 pathway. The modulation of transcriptional activity by NOC2L influences cancer cell proliferation and survival. It also relates to developmental disorders where alterations in gene expression during critical growth phases contribute to abnormal phenotypes. Interactions with the p53 protein further emphasize its role in maintaining cell integrity and responding to oncogenic events.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
See full target information NOC2L
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell division 18:17 PubMed37872600

2023

Preeclampsia-associated lncRNA FEZF1-AS1 regulates cell proliferation and apoptosis in placental trophoblast cells through the ELAVL1/NOC2L axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xudong Zhao,Fengyun Su,Qing Guo,Xiuhong Tao,Huifeng Wang,Hongling Wang,Qinwen Li,Wangmeng Zhang

International journal of molecular sciences 22: PubMed34070506

2021

Micellar Hyaluronidase and Spiperone as a Potential Treatment for Pulmonary Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Evgenii Skurikhin,Pavel Madonov,Olga Pershina,Natalia Ermakova,Angelina Pakhomova,Darius Widera,Edgar Pan,Mariia Zhukova,Lubov Sandrikina,Andrey Artamonov,Alexander Dygai
View all publications
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