Anti-Noelin antibody - C-terminal

Supplementary info

Activity summary

Noelin also known as Olfactomedin 1 (OLFM1) is a secreted glycoprotein with a molecular mass around 55 kDa. It is expressed in the central nervous system particularly within the brain and retina and also in some peripheral tissues. The protein plays roles in synaptic function due to its ability to bind to components within the extracellular matrix.

Biological function summary

Noelin contributes to the stabilization of synaptic structures and regulation of neuronal network formation. It interacts with other olfactomedin domain-containing proteins and forms complexes to mediate its functions. These interactions help maintain synaptic plasticity which is important for learning and memory processes.

Pathways

The target takes part in neural development and function. It is involved in the Wnt signaling pathway important for cellular communication in brain development. Noelin also interacts with axon guidance molecules like netrins facilitating proper neuronal network formation. This places Noelin in important roles where fine-tuning synaptic connectivity is necessary.

Associated diseases and disorders

Noelin has connections to neurological conditions such as schizophrenia and neurodegenerative diseases. Alterations in Noelin expression or function can disrupt synaptic connectivity potentially leading to these disorders. The protein interacts with other proteins like DISC1 in schizophrenia highlighting its importance in maintaining mental health.