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AB239520

Anti-Noggin antibody [A11]

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(3 Publications)

Mouse Monoclonal Noggin antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NOG.

View Alternative Names

Noggin, NOG

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Paraffin-embedded human pancreatic cancer tissue stained for Noggin with ab239520 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Paraffin-embedded human breast cancer tissue stained for Noggin with ab239520 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Paraffin-embedded human liver cancer tissue stained for Noggin with ab239520 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Noggin antibody [A11] (AB239520)

Paraffin-embedded human glioma tissue stained for Noggin with ab239520 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-Noggin antibody [A11] (AB239520)
  • WB

Supplier Data

Western blot - Anti-Noggin antibody [A11] (AB239520)

All lanes:

Western blot - Anti-Noggin antibody [A11] (ab239520) at 2 µg/mL

All lanes:

Recombinant human Noggin protein

Secondary

All lanes:

HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution

Predicted band size: 26 kDa

false

Western blot - Anti-Noggin antibody [A11] (AB239520)
  • WB

Supplier Data

Western blot - Anti-Noggin antibody [A11] (AB239520)

All lanes:

Western blot - Anti-Noggin antibody [A11] (ab239520) at 2 µg/mL

All lanes:

Rat placenta lysate

Secondary

All lanes:

HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution

Predicted band size: 26 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

A11

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NOG.

Q13253

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from TCS.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Noggin also known as noggin protein is a secreted glycoprotein with a mass of approximately 26 kDa. It antagonizes bone morphogenetic proteins (BMPs) by directly binding them preventing their interaction with receptors. This binding inhibits the signaling pathway which affects cellular processes such as differentiation growth and apoptosis. Noggin expresses prominently in embryonic tissues and in tissues undergoing differentiation particularly in the neural tube notochord and developing articular cartilage. The expression pattern suggests its importance during critical phases of development and tissue patterning.
Biological function summary

Noggin functions as an essential regulator in embryonic development sculpting tissues by inhibiting BMP activity. It does not work alone but functions as part of a complex regulatory network involving other BMP antagonists. By inhibiting BMPs Noggin plays an important role in neural tube closure limb formation and somite development. Noggin's activities help modulate the balance between proliferation and differentiation in these contexts allowing for proper structural formation during embryogenesis.

Pathways

Noggin operates mainly within the TGF-beta/BMP signaling pathway serving as a critical modulator. Inhibiting BMP through Noggin affects downstream targets connecting it to other signaling proteins like SMADs which mediate transcriptional responses. This control enables Noggin to indirectly regulate Wnt signaling as well showing its impact on various developmental stages and processes. Its influence on these pathways indicates Noggin’s importance in maintaining cellular homeostasis during growth and morphogenesis.

Noggin relates to conditions such as fibrodysplasia ossificans progressiva and cartilage-related abnormalities. Mutations or dysregulation of noggin protein can disrupt normal BMP signaling leading to aberrant skeletal development and calcification. This disruption often involves interactions with other proteins like BMP4 revealing Noggin's critical role in maintaining bone and cartilage integrity. Targeting noggin pathway components may provide therapeutic potential for addressing such conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed : 21976273, PubMed : 26643732).
See full target information NOG
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:33150 PubMed41006496

2025

Neonatal sevoflurane exposure enhances stress-related neurological susceptibility via NKCC1 modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Bi-Ying Yuan,Li-Hui Shan,Jiang Zou,Xiao-Hai Xie,Jia-Qi Gan,Ben-Zhen Chen

Cardiovascular research 120:2163-2165 PubMed39238367

2024

Identifying optimal reference genes for real-time quantitative polymerase chain reaction in human myocardial tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Camacho-Encina,Laura K Booth,Rachael Redgrave,Minna Honkanen-Scott,William E Scott,Carmen Martin-Ruiz,Guy MacGowan,Sarah Richardson,John Dark,Simon Tual-Chalot,Gavin D Richardson

International journal of molecular medicine 51: PubMed36524372

2022

Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojuan Su,Junjie Ying,Dongqiong Xiao,Xia Qiu,Shiping Li,Fengyan Zhao,Jun Tang
View all publications
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