Anti-NOL9 antibody [EPR9578]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NOL9 also known as Nucleolar Protein 9 is a protein encoded by the NOL9 gene. It has a molecular mass of approximately 150 kDa. This protein mainly localizes in the nucleolus a sub-region of the nucleus where it is highly expressed. NOL9 functions as a polynucleotide 5'-kinase which means it is involved in adding phosphate groups to the 5' end of RNA molecules. This activity plays an important role in processes such as RNA maturation.

Biological function summary

NOL9 participates in ribosome biogenesis which is the process of making ribosomes. It plays an important part in the processing and modification of precursor ribosomal RNA (pre-rRNA) into mature ribosomal RNA (rRNA) a task that is key for proper ribosome functionality. NOL9 functions within a multiprotein complex engaging with other nucleolar proteins to achieve efficient ribosomal RNA processing. The proper assembly and function of this complex ensure correct ribosome production a vital step for protein synthesis within the cell.

Pathways

NOL9 is involved in the rRNA processing pathway and ribosome assembly. It collaborates with other important proteins like fibrillarin and nucleolin to guide the transformation of pre-rRNA into functional rRNA components. This transformation is part of the ribosome biogenesis pathway which supports cellular growth and protein synthesis. The efficient functioning of NOL9 in these pathways helps maintain cellular homeostasis and protein production.

Associated diseases and disorders

NOL9 has been related to potential implications in cancer and genetic ribosomopathy. Its role in ribosome biogenesis links it to cancer as abnormal ribosome production can lead to uncontrolled cell division and growth. NOL9's interaction with proteins like nucleophosmin an oncogenic protein suggests a possible involvement in tumor progression. Additionally mutations or dysfunctions in NOL9 may contribute to ribosomopathy disorders linked to errors in ribosome function which includes conditions like Diamond-Blackfan Anemia.