AB2778

Anti-Nonspecific Cytotoxic Cells antibody [5C.6]

Name: Anti-Nonspecific Cytotoxic Cells antibody [5C.6] (ab2778) | Abcam
Brand: Abcam Limited
SKU: AB2778
Price: 520 USD
Availability: InStock

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(2 Publications)

Mouse Monoclonal Nonspecific Cytotoxic Cells antibody. Suitable for IP, Flow Cyt, ELISA, WB, FuncS (Neut/Block) and reacts with Rat, Pig, Catfish, Tilapia, Dog, Horse, Cow samples. Cited in 2 publications.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

5C.6

Isotype

IgM

Carrier free

Reacts with

Rat, Horse, Cow, Dog, Pig, Tilapia, Catfish

Applications

ELISA, IP, FuncS (Neut/Block), Flow Cyt, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "By Western blot, this antibody detects a 32 kDa protein representing nonspecific cytotoxic cell receptor protein.", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "" }, "Catfish": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "By Western blot, this antibody detects a 32 kDa protein representing nonspecific cytotoxic cell receptor protein.", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "" }, "Cow": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "By Western blot, this antibody detects a 32 kDa protein representing nonspecific cytotoxic cell receptor protein.", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "" }, "Dog": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "By Western blot, this antibody detects a 32 kDa protein representing nonspecific cytotoxic cell receptor protein.", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "" }, "Horse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "By Western blot, this antibody detects a 32 kDa protein representing nonspecific cytotoxic cell receptor protein.", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "" }, "Pig": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "By Western blot, this antibody detects a 32 kDa protein representing nonspecific cytotoxic cell receptor protein.", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "" }, "Tilapia": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "By Western blot, this antibody detects a 32 kDa protein representing nonspecific cytotoxic cell receptor protein.", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "" } } }

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Product details

U.S. Patent Numbers: 5,028,424 and 5,229,494.

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Properties and storage information

Form

Liquid

Purity

IgM fraction

Storage buffer

Preservative: 0.05% Sodium azide Constituents: 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Nonspecific Cytotoxic Cells also recognized as NC cells serve an important function in the immune system by targeting and killing virally infected cells and tumor cells without prior sensitization. These cells are a component of the innate immune system and are similar in function to natural killer (NK) cells. Unlike NK cells NC cells do not require specific antigen recognition. Their precise molecular mechanisms remain less defined than other immune cells and their molecular mass is not distinctly characterized. NC cells are primarily found in peripheral blood and lymphoid tissues where they execute their cytotoxic action.

Biological function summary

These immune cells play an important defensive role by eliminating cells that might otherwise evade the adaptive immune response. NC cells achieve this through the release of cytotoxins that induce apoptosis in target cells. They are not known to be part of multi-protein complexes and their activity is largely independent acting through perforin and granzymes. Their function also overlaps with natural killer cells and they contribute to bridging innate and adaptive immunity due to their rapid response capabilities.

Pathways

Nonspecific cytotoxic cells engage with key immune-related pathways such as the innate immune response pathway and the apoptosis signaling pathway. In the innate immune response they interact with proteins such as perforin and granzymes which are important for their cytotoxic activity. The apoptosis signaling pathway involves these cytotoxins leading to the programmed cell death of target cells. Their role in these pathways highlights their importance in initial immune defense and regulation of cell survival.

Nonspecific cytotoxic cells show relevance to conditions like viral infections and cancer. They are a critical early defense against viral infections where their ability to kill infected cells minimizes viral spread. These cells also hold implications in cancer where their ability to recognize and eliminate tumor cells aids in tumor surveillance. The activity of proteins like perforin links NC cells to these diseases as both the defense against infection and tumor surveillance rely on efficient cytotoxic mechanisms.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Nonspecific Cytotoxic Cells

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Advanced functional materials 30: PubMed34211359

2020

Metabolic Labeling to Probe the Spatiotemporal Accumulation of Matrix at the Chondrocyte-Hydrogel Interface.

Applications

Unspecified application

Species

Unspecified reactive species

Claudia Loebel,Mi Y Kwon,Chao Wang,Lin Han,Robert L Mauck,Jason A Burdick

Molecular immunology 34:955-65 PubMed9464530

1997

NCCRP-1: a novel receptor protein sequenced from teleost nonspecific cytotoxic cells.

Applications

Unspecified application

Species

Unspecified reactive species

L Jaso-Friedmann,J H Leary,D L Evans

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Nonspecific Cytotoxic Cells antibody [5C.6]

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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