Anti-Noradrenaline antibody [EPR24435-114]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Noradrenaline also known as norepinephrine is a neurotransmitter and hormone with a molecular weight of approximately 169.18 g/mol. It is primarily synthesized and released by neurons in the central nervous system and sympathetic nervous system from the adrenal medulla. Noradrenaline functions mechanically by acting on adrenergic receptors including alpha and beta subtypes which are distributed widely in the body. These receptors facilitate its major roles in various physiological responses such as modulation of heart rate focus and alertness.

Biological function summary

Noradrenaline plays significant roles in the fight-or-flight response and regulation of mood and blood pressure. As part of the catecholamine family noradrenaline often works in conjunction with other neurotransmitters like dopamine. It is involved in the formation of synaptic networks and influences neuronal signaling through its action on adrenergic receptors located in multiple tissues including the heart vasculature and brain. It does not form part of a molecular complex but interacts dynamically with several proteins that mediate its effects.

Pathways

Noradrenaline participates in the adrenergic signaling pathway influencing cardiovascular and metabolic processes. Within this pathway it regulates functions by interacting with proteins such as adrenergic receptors and modulates the release of neurotransmitters like serotonin. Additionally the stress response pathway also known as the hypothalamic-pituitary-adrenal axis significantly involves noradrenaline to regulate stress-related hormone synthesis and secretion affecting various bodily systems.

Associated diseases and disorders

Noradrenaline shows connections to cardiovascular disorders and mood disorders such as depression. Abnormal noradrenaline levels can lead to hypertension by increasing peripheral vascular resistance alongside the involvement of proteins like beta-adrenergic receptors. In mood disorders dysregulation of noradrenaline along with dopamine and serotonin contributes to the pathophysiology of depression highlighting the complex neurochemical interactions affecting mental health.