Anti-Norbin antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Norbin also known as neurochondrin is a protein with a mass of approximately 80 kDa. It is expressed widely in the central nervous system with significant levels present in neurons. Norbin plays a mechanical role by interacting directly with various signaling proteins acting as an anchor within cell signaling frameworks. The interactions help regulate multiple cellular processes important for neuronal function and communication indicating Norbin's significance in neurophysiological activities.

Biological function summary

The actions of proteins within the cell often influence cellular signaling and communication. Norbin is a part of several protein complexes assisting in the regulation of signal transduction pathways particularly those involving G-protein-coupled receptors (GPCRs). These interactions highlight Norbin's role in maintaining synaptic function and neuronal excitability. Norbin also affects synaptic plasticity contributing to learning and memory processes by modulating neurotransmission efficiency.

Pathways

Various signaling processes within cells are interlinked and Norbin integrates into the calcium signaling and MAPK pathways. In these pathways Norbin interacts closely with proteins like mGluR5 (a type of metabotropic glutamate receptor) to mediate downstream effects on neuronal activity and development. This association impacts cellular processes by controlling cellular responses to environmental stimuli thereby affecting overall nervous system functionality.

Associated diseases and disorders

Proteins and pathways often correlate with specific conditions. Norbin's involvement with neurophysiological pathways links it to neurological disorders such as schizophrenia and Alzheimer's disease. During disease states altered Norbin expression or dysregulation may impact its interaction with proteins like mGluR5 exacerbating symptoms or progression of these conditions. Research into Norbin's role offers potential therapeutic insights into these neurological disorders.