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AB88877

Anti-Norbin antibody

4

(1 Review)

|

(4 Publications)

Mouse Polyclonal Norbin antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NCDN.

View Alternative Names

KIAA0607, NCDN, Neurochondrin

2 Images
Western blot - Anti-Norbin antibody (AB88877)
  • WB

Unknown

Western blot - Anti-Norbin antibody (AB88877)

All lanes:

Western blot - Anti-Norbin antibody (ab88877) at 1/500 dilution

All lanes:

rat brain tissue lysate at 50 µg

Predicted band size: 79 kDa

Observed band size: 79 kDa

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Western blot - Anti-Norbin antibody (AB88877)
  • WB

Unknown

Western blot - Anti-Norbin antibody (AB88877)

All lanes:

Western blot - Anti-Norbin antibody (ab88877) at 1/500 dilution

Lane 1:

Norbin transfected 293T cell lysate at 25 µg

Lane 2:

Non transfected 293T cell lysate at 25 µg

Predicted band size: 79 kDa

Observed band size: 79 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NCDN.

Q9UBB6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Norbin also known as neurochondrin is a protein with a mass of approximately 80 kDa. It is expressed widely in the central nervous system with significant levels present in neurons. Norbin plays a mechanical role by interacting directly with various signaling proteins acting as an anchor within cell signaling frameworks. The interactions help regulate multiple cellular processes important for neuronal function and communication indicating Norbin's significance in neurophysiological activities.
Biological function summary

The actions of proteins within the cell often influence cellular signaling and communication. Norbin is a part of several protein complexes assisting in the regulation of signal transduction pathways particularly those involving G-protein-coupled receptors (GPCRs). These interactions highlight Norbin's role in maintaining synaptic function and neuronal excitability. Norbin also affects synaptic plasticity contributing to learning and memory processes by modulating neurotransmission efficiency.

Pathways

Various signaling processes within cells are interlinked and Norbin integrates into the calcium signaling and MAPK pathways. In these pathways Norbin interacts closely with proteins like mGluR5 (a type of metabotropic glutamate receptor) to mediate downstream effects on neuronal activity and development. This association impacts cellular processes by controlling cellular responses to environmental stimuli thereby affecting overall nervous system functionality.

Proteins and pathways often correlate with specific conditions. Norbin's involvement with neurophysiological pathways links it to neurological disorders such as schizophrenia and Alzheimer's disease. During disease states altered Norbin expression or dysregulation may impact its interaction with proteins like mGluR5 exacerbating symptoms or progression of these conditions. Research into Norbin's role offers potential therapeutic insights into these neurological disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed : 33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable).
See full target information NCDN
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Psychopharmacology 240:2617-2629 PubMed37707611

2023

Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid.

Applications

Unspecified application

Species

Unspecified reactive species

Simona D'Antoni,Sara Schiavi,Valeria Buzzelli,Samuele Giuffrida,Alessandro Feo,Fabrizio Ascone,Carla Letizia Busceti,Ferdinando Nicoletti,Viviana Trezza,Maria Vincenza Catania

Life (Basel, Switzerland) 12: PubMed35330215

2022

Changes in mGlu5 Receptor Signaling Are Associated with Associative Learning and Memory Extinction in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Elena Teleuca,Giovanni Sebastiano Alemà,Paola Casolini,Ilaria Barberis,Francesco Ciabattoni,Rosamaria Orlando,Luisa Di Menna,Luisa Iacovelli,Maria Rosaria Scioli,Ferdinando Nicoletti,Anna Rita Zuena

Journal of orthopaedic research : official publica 34:1316-26 PubMed27018499

2016

Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyan Tang,Liufang Jing,William J Richardson,Robert E Isaacs,Robert D Fitch,Christopher R Brown,Melissa M Erickson,Lori A Setton,Jun Chen

PloS one 7:e52020 PubMed23284858

2012

Changes in the molecular phenotype of nucleus pulposus cells with intervertebral disc aging.

Applications

ICC/IF

Species

Rat

Xinyan Tang,Liufang Jing,Jun Chen
View all publications
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