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AB317154

Anti-Norovirus VP1 antibody [HL2177]

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Rabbit Recombinant Monoclonal ORF2 antibody. Suitable for WB, ICC/IF and reacts with Transfected cell lysate - Norovirus, Transfected cell line - Norovirus samples.
1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Norovirus VP1 antibody [HL2177] (AB317154)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Norovirus VP1 antibody [HL2177] (AB317154)

ab317154 detects Norovirus VP1 protein by immunofluorescent analysis. Sample : Mock and transfected 293T cells were fixed in 4% paraformaldehyde at RT for 15 min. Green : Norovirus VP1 stained by ab317154 diluted at 1 : 500. Blue : Fluoroshield with DAPI.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

HL2177

Isotype

IgG

Carrier free

No

Reacts with

Norovirus

Applications

WB, ICC/IF

applications

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Norovirus Capsid protein VP1 antibody [EPR27186-20] (AB308068)

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AB308069

Anti-Norovirus Capsid protein VP1 antibody [EPR27186-20] - BSA and Azide free

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Norovirus Capsid protein VP1 antibody [EPR27186-20] - BSA and Azide free (AB308069)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Norovirus": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Transfected cell line - Norovirus": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500", "ICCIF-species-notes": "<p></p>" }, "Transfected cell lysate - Norovirus": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Product details

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Norovirus Capsid protein VP1 also known as the Norwalk Capsid protein is a major structural component of noroviruses. The mass of this protein is approximately 58 kilodaltons. It is expressed within the viral particles forming the outer shell or capsid which plays an important role in protection and infectivity of the virus. VP1 is also the main target for capsid ELISA tests which are employed for virus detection.
Biological function summary

Norovirus Capsid protein VP1 assembles into icosahedral particles forming the structure that encases the viral RNA. It works as part of a complex with other molecular groups to facilitate the virus’s entry into host cells by binding to histo-blood group antigens found on epithelial cells of the digestive tract. This protein’s structure allows it to adapt and evade the host immune response which plays role in the virus's infectivity.

Pathways

Norovirus Capsid protein VP1 involves in pathways related to viral replication and immune evasion. Inside the host it participates in interactions that inhibit immune signaling pathways. These interactions often involve proteins like the Golgi-associated mechanics to promote efficient assembly and release of viral particles. VP1's interaction with cellular machinery ensures ongoing propagation of the virus.

The Norovirus Capsid protein VP1 directly connects to gastroenteritis a leading cause of acute viral gastroenteritis. It links to disease progression by aiding viral invasion and persistence in the gastrointestinal tract. The VP1's interactions with the immune system and histo-blood group antigens contribute to high transmissibility and variability of infection severity among different individuals.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ORF2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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