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AB106535

Anti-NOS-1 antibody

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(3 Publications)

Rabbit Polyclonal NOS-1 antibody. Suitable for WB and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human NANOS1.

View Alternative Names

NOS1, NANOS1, Nanos homolog 1, NOS-1, EC_Rep1a

1 Images
Western blot - Anti-NOS-1 antibody (AB106535)
  • WB

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Western blot - Anti-NOS-1 antibody (AB106535)

Lane 1:

Western blot - Anti-NOS-1 antibody (ab106535) at 1 µg/mL

Lane 2:

Western blot - Anti-NOS-1 antibody (ab106535) at 2 µg/mL

All lanes:

Rat brain lysate at 15 µg

Predicted band size: 30 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human NANOS1. The exact immunogen used to generate this antibody is proprietary information.

Q8WY41

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Nitric oxide synthase 1 (NOS-1) also known as neuronal NOS (nNOS) is an enzyme responsible for the production of nitric oxide (NO) from L-arginine. This activity involves a NADPH-dependent reaction. NOS-1 has a molecular mass of about 160 kDa and is mainly expressed in the central and peripheral nervous systems as well as in skeletal muscle. It plays a major role in neurotransmission by generating NO a small signaling molecule.
Biological function summary

Nitric oxide generated by NOS-1 is important in synaptic plasticity which underlies learning and memory processes. It also regulates the release of neurotransmitters acting as a neuromodulator. NOS-1 operates as a homodimer but it does not form part of a larger complex. The enzyme displays a significant role in modulating neuronal communication contributing to nerve cell survival and controlling cerebral blood flow.

Pathways

Nitric oxide produced by NOS-1 engages in the nitric oxide signaling pathway influencing the cyclic GMP (cGMP) pathway. This involves the activation of guanylate cyclase which catalyzes the conversion of GTP to cGMP resulting in various neuronal outcomes. Additionally NOS-1 participates in the calcium/calmodulin-dependent pathway where its activity is tightly regulated by intracellular calcium levels. The enzyme interacts with proteins such as PSD-95 a postsynaptic density protein which influences its localization and activity.

Dysregulation of NOS-1 is linked to neurodegenerative diseases like Alzheimer’s and conditions like stroke. Aberrant NO production leads to harmful oxidative stress. In Alzheimer's modulating NOS-1 activity interacts with amyloid beta accumulation contributing to the pathology. During stroke excess NO causes neuronal damage and impairs recovery processes. Protein interactions with calmodulin affect NOS-1 function in these pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
See full target information NANOS1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Iranian journal of parasitology 19:131-139 PubMed39011528

2024

Comparative Analysis of and Genes Expression in the Germinative Cells Isolated from Germinal Layer and the Neck Region of .

Applications

Unspecified application

Species

Unspecified reactive species

Amin Yazdani,Narges Khamesi,Alireza Keyhani,Saeid Nasibi,Mohammad Ali Mohammadi,Seyed Mohammad Mousavi,Ali Derakhshani,Majid Fasihi Harandi

Nature biotechnology 40:885-895 PubMed35190686

2022

Saturation variant interpretation using CRISPR prime editing.

Applications

Unspecified application

Species

Unspecified reactive species

Steven Erwood,Teija M I Bily,Jason Lequyer,Joyce Yan,Nitya Gulati,Reid A Brewer,Liangchi Zhou,Laurence Pelletier,Evgueni A Ivakine,Ronald D Cohn

Folia neuropathologica 58:45-56 PubMed32337957

2020

PARP1 might enhance the therapeutic effect of tetrahydroxystilbene glucoside in traumatic brain injury via inhibition of Ras/JNK signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yiqiang Cao,Yu Chen,Fei Wang,Yonggang Wang,Jiang Long
View all publications
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Product promise

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