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Rabbit Recombinant Monoclonal Notch2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Notch2.
Alternative names=Neurogenic locus notch homolog protein 2, Notch 2, hN2, NOTCH2
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.02% Proclin 300
Constituents: 99% PBS- Form
Liquid
- Clonality
Monoclonal
- Immunogen
Recombinant Fragment Protein within Mouse Notch2. The exact immunogen used to generate this antibody is proprietary information. Database link: O35516
Reactivity data
Select an application| ICC/IF | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
Images
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Target data
Function
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
Recommended products
Rabbit Recombinant Monoclonal Notch2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Notch2.
Alternative names=Neurogenic locus notch homolog protein 2, Notch 2, hN2, NOTCH2
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.02% Proclin 300
Constituents: 99% PBS- Form
Liquid
- Clonality
Monoclonal
- Immunogen
Recombinant Fragment Protein within Mouse Notch2. The exact immunogen used to generate this antibody is proprietary information. Database link: O35516
- Clone number
B9
- Purification technique
Affinity purification Protein A
- Specificity
An engineered ScFv fragment antibody that binds to both mouse mNRR2 and human hNRR2 but not NRR1.
- Light chain type
kappa
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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