AB93388

Anti-NOX3 antibody

Be the first to review this product! Submit a review

(2 Publications)

Rabbit Polyclonal NOX3 antibody. Suitable for ELISA, WB and reacts with Recombinant fragment samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NOX3.

View Alternative Names

MOX2, NOX3, NADPH oxidase 3, Mitogenic oxidase 2, gp91phox homolog 3, MOX-2, GP91-3

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Applications

ELISA, WB

applications

Immunogen

Synthetic Peptide within Human NOX3. The exact immunogen used to generate this antibody is proprietary information.

Q9HBY0

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.</p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Purity >90%

Storage buffer

pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NOX3 also known as NADPH oxidase 3 is an enzyme that produces reactive oxygen species (ROS) by transferring electrons from NADPH to oxygen. It has a molecular mass of approximately 65 kDa. This protein is expressed mainly in inner ear tissues and to a lesser extent in other tissues. NOX3's primary role involves generating superoxide anions which contribute to cellular processes and signaling pathways.

Biological function summary

NOX3 generates ROS as part of the inner ear's response mechanisms. Although its function is still being studied NOX3 is part of a larger enzymatic complex which includes other NADPH oxidase subunits like p22phox and NOXO1. This complex enables precise regulation of ROS production impacting hearing and balance.

Pathways

The ROS production by NOX3 plays a role in signaling pathways related to oxidative stress. It is involved in pathways such as the NOX-AKT signaling pathway which interacts with proteins like AKT1 a kinase critical for cell survival and proliferation. NOX3's ROS generation affects cellular redox states influencing various downstream molecular events.

NOX3 has associations with conditions such as hearing loss and inner ear disorders. The imbalance of ROS production by NOX3 may lead to oxidative damage in the ear contributing to these conditions. Other proteins such as SOD1 which helps mitigate oxidative stress interact indirectly with NOX3 providing potential therapeutic targets for addressing NOX3-related disorders.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor, upon formation of a complex with CYBA/p22phox (PubMed : 15181005, PubMed : 15824103). Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity).

See full target information NOX3

style

left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Gene therapy 29:81-93 PubMed34257417

2021

Restoration of RPGR expression in vivo using CRISPR/Cas9 gene editing.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica D Gumerson,Amal Alsufyani,Wenhan Yu,Jingqi Lei,Xun Sun,Lijin Dong,Zhijian Wu,Tiansen Li

Neurotoxicity research 36:712-723 PubMed31016687

2019

Engagement of MicroRNA-155 in Exaggerated Oxidative Stress Signal and TRPA1 in the Dorsal Horn of the Spinal Cord and Neuropathic Pain During Chemotherapeutic Oxaliplatin.

Applications

Unspecified application

Species

Unspecified reactive species

Fenghua Miao,Rong Wang,Guozhen Cui,Xiaoguang Li,Ting Wang,Xue Li

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-NOX3 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Product promise