Anti-NOX5 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NOX5 also known as NADPH oxidase 5 is a member of the NADPH oxidase family which has a molecular mass of approximately 82 kDa. NOX5 is expressed widely across various tissues including the testes spleen and the fetal kidney. It is distinct because it can generate reactive oxygen species (ROS) in response to changes in intracellular calcium levels operating independently from the activation of other related NADPH oxidase enzymes.

Biological function summary

NOX5 plays a role in producing reactive oxygen species which are important for cellular signaling. The protein sometimes functions as an independent enzyme and does not typically form a complex with other proteins. Its calcium-binding domain is essential for its activity allowing it to respond dynamically to cellular changes. This ability to modulate ROS production implicates NOX5 in processes like cell proliferation migration and endothelial function.

Pathways

NOX5 contributes to cellular oxidative stress response and angiogenesis. The enzyme's activity in ROS generation links it with the MAPK signaling pathway which is important for cell differentiation and senescence. Additionally it's associated with the calcium signaling pathway interacting with proteins such as calmodulin which modulate its activity. These interactions ensure NOX5's role in balancing cellular oxidative signaling and responding to calcium fluctuations.

Associated diseases and disorders

NOX5 is linked with hypertension and cancer. The enzyme's involvement in ROS production can lead to oxidative stress contributing to vascular dysfunction and the pathogenesis of hypertension. In cancer NOX5-related ROS generation can promote tumor growth and metastasis. It shares connections with other oxidative stress-related proteins like NOX1 and NOX2 which also have critical roles in disease progression through similar mechanisms.