Anti-NOXA1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NOXA1 also known as NADPH oxidase activator 1 functions as an important regulatory component in the assembly and activation of the NADPH oxidase complex. This protein has a mass of approximately 57 kDa. It is usually expressed in various tissues including the pancreas and lung indicating its diverse role in physiological processes. NOXA1 works by facilitating the production of reactive oxygen species (ROS) through stimulating the activity of NADPH oxidase an important action for cellular signaling and defense.

Biological function summary

The NOXA1 protein interacts in the complex environment of intracellular processes. It forms part of the NADPH oxidase complex influencing ROS generation which plays a role in cell signaling microbial killing and maintaining vascular tone. Through these functions NOXA1 contributes to normal and pathological conditions by promoting oxidative stress ultimately affecting both immune responses and cellular communications.

Pathways

NOXA1 associates significantly with the superoxide production pathway through its action in NADPH oxidase complexes. It interacts closely with proteins like p67phox and p47phox important for proper complex activation and function. NOXA1 also participates in the signaling pathway related to inflammation where it modulates the immune response alongside proteins such as Rac1 and Rac2. These interactions place NOXA1 in key regulatory roles within these biological pathways.

Associated diseases and disorders

NOXA1 links to various oxidative stress-related conditions. For example chronic granulomatous disease features dysfunctional NADPH oxidase activity in which NOXA1's proper function is compromised. Additionally NOXA1 exhibits connections to cardiovascular disorders as its role in producing reactive oxygen species can exacerbate oxidative damage contributing to disease progression. Proteins like gp91phox are also involved in these conditions highlighting NOXA1's significance in these contexts.