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AB68523

Anti-NOXA1 antibody

5

(1 Review)

|

(6 Publications)

Mouse Polyclonal NOXA1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NOXA1.

View Alternative Names

P51NOX, NOXA1, NADPH oxidase activator 1, NOX activator 1, Antigen NY-CO-31, NCF2-like protein, P67phox-like factor, p51-nox

1 Images
Western blot - Anti-NOXA1 antibody (AB68523)
  • WB

Unknown

Western blot - Anti-NOXA1 antibody (AB68523)

All lanes:

Western blot - Anti-NOXA1 antibody (ab68523) at 1/500 dilution

Lane 1:

NOXA1 transfected 293T lysate at 25 µg

Lane 2:

Non-transfected 293T lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 51 kDa

Observed band size: 60 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NOXA1.

Q86UR1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NOXA1 also known as NADPH oxidase activator 1 functions as an important regulatory component in the assembly and activation of the NADPH oxidase complex. This protein has a mass of approximately 57 kDa. It is usually expressed in various tissues including the pancreas and lung indicating its diverse role in physiological processes. NOXA1 works by facilitating the production of reactive oxygen species (ROS) through stimulating the activity of NADPH oxidase an important action for cellular signaling and defense.
Biological function summary

The NOXA1 protein interacts in the complex environment of intracellular processes. It forms part of the NADPH oxidase complex influencing ROS generation which plays a role in cell signaling microbial killing and maintaining vascular tone. Through these functions NOXA1 contributes to normal and pathological conditions by promoting oxidative stress ultimately affecting both immune responses and cellular communications.

Pathways

NOXA1 associates significantly with the superoxide production pathway through its action in NADPH oxidase complexes. It interacts closely with proteins like p67phox and p47phox important for proper complex activation and function. NOXA1 also participates in the signaling pathway related to inflammation where it modulates the immune response alongside proteins such as Rac1 and Rac2. These interactions place NOXA1 in key regulatory roles within these biological pathways.

NOXA1 links to various oxidative stress-related conditions. For example chronic granulomatous disease features dysfunctional NADPH oxidase activity in which NOXA1's proper function is compromised. Additionally NOXA1 exhibits connections to cardiovascular disorders as its role in producing reactive oxygen species can exacerbate oxidative damage contributing to disease progression. Proteins like gp91phox are also involved in these conditions highlighting NOXA1's significance in these contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
See full target information NOXA1
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 10:143 PubMed30760703

2019

Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas.

Applications

Unspecified application

Species

Unspecified reactive species

Tiphany Coralie De Bessa,Alessandra Pagano,Ana Iochabel Soares Moretti,Percillia Victoria Santos Oliveira,Samir Andrade Mendonça,Herve Kovacic,Francisco Rafael Martins Laurindo

Oncotarget 8:103710-103730 PubMed29262595

2017

Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mathieu Chocry,Ludovic Leloup,Hervé Kovacic

Food & function 6:1218-28 PubMed25736858

2015

The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics.

Applications

Unspecified application

Species

Unspecified reactive species

Tina Guina,Monica Deiana,Simone Calfapietra,Barbara Cabboi,Marco Maina,Carlo I Tuberoso,Gabriella Leonarduzzi,Paola Gamba,Simona Gargiulo,Gabriella Testa,Giuseppe Poli,Fiorella Biasi

Circulation research 115:911-8 PubMed25228390

2014

Phosphorylation of Nox1 regulates association with NoxA1 activation domain.

Applications

Unspecified application

Species

Unspecified reactive species

Jennifer Streeter,Brandon M Schickling,Shuxia Jiang,Bojana Stanic,William H Thiel,Lokesh Gakhar,Jon C D Houtman,Francis J Miller

Free radical biology & medicine 51:1116-25 PubMed21586323

2011

Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2.

Applications

WB

Species

Human

Gábor Csányi,Eugenia Cifuentes-Pagano,Imad Al Ghouleh,Daniel J Ranayhossaini,Loreto Egaña,Lucia R Lopes,Heather M Jackson,Eric E Kelley,Patrick J Pagano

Free radical biology & medicine 47:1731-41 PubMed19778604

2009

Pro-oxidant and proapoptotic effects of cholesterol oxidation products on human colonic epithelial cells: a potential mechanism of inflammatory bowel disease progression.

Applications

IP

Species

Human

Fiorella Biasi,Cinzia Mascia,Marco Astegiano,Elena Chiarpotto,Mario Nano,Barbara Vizio,Gabriella Leonarduzzi,Giuseppe Poli
View all publications
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