Rabbit Polyclonal NPFF antibody. Suitable for IHC-Fr and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human Pro-FMRFamide-related neuropeptide FF.
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Publications
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- Parasitology 150:612-6222023An examination of nervous system revealed unexpected immunoreactivity of both secretory apparatus and excretory canals in plerocercoids of two broad tapeworms (Cestoda: Diphyllobothriidea).Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniel Barčák,Anna Alexovič Matiašová,Eva Čisovská Bazsalovicsová,Miroslava Soldánová,Mikuláš Oros,Ivica Králová-HromadováPubMed 36938799
- Parasites & vectors 12:4082019Complex insight on microanatomy of larval "human broad tapeworm" Dibothriocephalus latus (Cestoda: Diphyllobothriidea).Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniel Barčák et. al.PubMed 31434579
- PloS one 11:e01656492016Development of the Nervous System of Carinina ochracea (Palaeonemer-tea, Nemertea).
- Biology open 3:50-82014Differential expression of the FMRF gene in adult and hatchling stellate ganglia of the squid Loligo pealei.Applications:IHCReactive species:Unspecified reactive speciesJ Peter H Burbach et. al.PubMed 24326188
- EvoDevo 2:122011Multiple Sox genes are expressed in stem cells or in differentiating neuro-sensory cells in the hydrozoan Clytia hemisphaerica.
- PloS one 4:e42312009Are Hox genes ancestrally involved in axial patterning? Evidence from the hydrozoan Clytia hemisphaerica (Cnidaria).Applications:IHC-FrReactive species:Unspecified reactive speciesRoxane Chiori et. al.PubMed 19156208
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: Whole serum- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human Pro-FMRFamide-related neuropeptide FF. The exact immunogen used to generate this antibody is proprietary information. Database link O15130
Reactivity data
Select an application| IHC-Fr | |
|---|---|
| Rat | Tested |
IHC-Fr
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/200 - 1/1000 | Notes - |
Target data
Function
Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.
Alternative names
Pro-FMRFamide-related neuropeptide FF, FMRFamide-related peptides, NPFF
Recommended products
Rabbit Polyclonal NPFF antibody. Suitable for IHC-Fr and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human Pro-FMRFamide-related neuropeptide FF.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: Whole serum- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human Pro-FMRFamide-related neuropeptide FF. The exact immunogen used to generate this antibody is proprietary information. Database link O15130
- Purity
- Whole antiserum
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Phe Met Arg Phe-NH2, a tetrapeptide neurotransmitter, a member of the same family of RFamide peptides as FLRFamide, sharing the same C terminal RFamide sequence. FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL Gene encodes a preproprotein where upon cleavage forms two active peptides possessing similar function.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Neuropeptide FF (NPFF) also known as FMRFamide-related peptide acts as a significant neuromodulator in the nervous system. NPFF weighs approximately 1200 daltons and appears in high concentrations in the central nervous system particularly in the spinal cord and hypothalamus. This peptide belongs to the RFamide family of neuropeptides. Researchers have identified RFamide peptides for roles in pain modulation and various autonomic processes.
- Biological function summary
The RFamide neuropeptides including NPFF influence pain perception and analgesia. NPFF does not explicitly form part of a complex but it interacts closely with specific receptors namely NPFF1 and NPFF2. These receptors mediate the diverse physiological responses induced by NPFF. Studies demonstrate NPFF's capability to inhibit the effects of opioids highlighting its involvement in the body's pain-control network.
- Pathways
The NPFF system plays a role in multiple signaling cascades connected to pain and stress responses. NPFF engages in the opioid receptor pathways impacting how the body processes discomfort and analgesics. Several interactions link NPFF to proteins like opioid receptors and adrenal corticotropic hormone (ACTH). These interactions help regulate the body's response to pain stress and hormone release.
- Associated diseases and disorders
NPFF connections to pain-related conditions and opioid dependency emerge as important research areas. The modulation of opioid effects by NPFF highlights its potential link to the mechanisms of opioid addiction. Additionally NPFF associations with chronic pain disorders suggest a possible therapeutic target. The dynamic between NPFF its receptors and opioid receptors characterizes the complex interplay affecting pain management and addiction response.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Frozen sections) - Anti-NPFF antibody (ab10352)
Immunohistochemical analysis of frozen sections of rat hypothalamus labeling NPFF with ab10352 at 1/200 dilution.
Immunohistochemistry (Frozen sections) - Anti-NPFF antibody (ab10352)
ab10352 staining NPFF in rat spinal cord by Immunohistochemistry (PFA perfusion fixed frozen sections).
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