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AB10352

Anti-NPFF antibody

4

(1 Review)

|

(7 Publications)

Rabbit Polyclonal NPFF antibody. Suitable for IHC-Fr and reacts with Rat samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human Pro-FMRFamide-related neuropeptide FF.

View Alternative Names

Pro-FMRFamide-related neuropeptide FF, FMRFamide-related peptides, NPFF

2 Images
Immunohistochemistry (Frozen sections) - Anti-NPFF antibody (AB10352)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-NPFF antibody (AB10352)

Immunohistochemical analysis of frozen sections of rat hypothalamus labeling NPFF with ab10352 at 1/200 dilution.

Immunohistochemistry (Frozen sections) - Anti-NPFF antibody (AB10352)
  • IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-NPFF antibody (AB10352)

ab10352 staining NPFF in rat spinal cord by Immunohistochemistry (PFA perfusion fixed frozen sections).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-Fr

applications

Immunogen

Synthetic Peptide within Human Pro-FMRFamide-related neuropeptide FF. The exact immunogen used to generate this antibody is proprietary information.

O15130

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/200 - 1/1000", "IHCFr-species-notes": "<p></p>" } } }
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Product details

Phe Met Arg Phe-NH2, a tetrapeptide neurotransmitter, a member of the same family of RFamide peptides as FLRFamide, sharing the same C terminal RFamide sequence. FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL Gene encodes a preproprotein where upon cleavage forms two active peptides possessing similar function.
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Preservative: 0.05% Sodium azide Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuropeptide FF (NPFF) also known as FMRFamide-related peptide acts as a significant neuromodulator in the nervous system. NPFF weighs approximately 1200 daltons and appears in high concentrations in the central nervous system particularly in the spinal cord and hypothalamus. This peptide belongs to the RFamide family of neuropeptides. Researchers have identified RFamide peptides for roles in pain modulation and various autonomic processes.
Biological function summary

The RFamide neuropeptides including NPFF influence pain perception and analgesia. NPFF does not explicitly form part of a complex but it interacts closely with specific receptors namely NPFF1 and NPFF2. These receptors mediate the diverse physiological responses induced by NPFF. Studies demonstrate NPFF's capability to inhibit the effects of opioids highlighting its involvement in the body's pain-control network.

Pathways

The NPFF system plays a role in multiple signaling cascades connected to pain and stress responses. NPFF engages in the opioid receptor pathways impacting how the body processes discomfort and analgesics. Several interactions link NPFF to proteins like opioid receptors and adrenal corticotropic hormone (ACTH). These interactions help regulate the body's response to pain stress and hormone release.

NPFF connections to pain-related conditions and opioid dependency emerge as important research areas. The modulation of opioid effects by NPFF highlights its potential link to the mechanisms of opioid addiction. Additionally NPFF associations with chronic pain disorders suggest a possible therapeutic target. The dynamic between NPFF its receptors and opioid receptors characterizes the complex interplay affecting pain management and addiction response.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.
See full target information Pro-FMRFamide-related neuropeptide FF
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cellular and infection microbiology 14:1415162 PubMed38919702

2024

The muscle and neural architecture of cysticerci revisited; implications on head-tail polarization of the larvae.

Applications

Unspecified application

Species

Unspecified reactive species

Arturo Calderón-Gallegos,Miguel Tapia-Rodríguez,Karel Estrada,Diana G Rios-Valencia,Patricia de la Torre,Nicolás Castellanos-de Oteyza,Miguel A Morales,Raúl J Bobes,Juan P Laclette

Parasitology 150:612-622 PubMed36938799

2023

An examination of nervous system revealed unexpected immunoreactivity of both secretory apparatus and excretory canals in plerocercoids of two broad tapeworms (Cestoda: Diphyllobothriidea).

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Barčák,Anna Alexovič Matiašová,Eva Čisovská Bazsalovicsová,Miroslava Soldánová,Mikuláš Oros,Ivica Králová-Hromadová

Parasites & vectors 12:408 PubMed31434579

2019

Complex insight on microanatomy of larval "human broad tapeworm" Dibothriocephalus latus (Cestoda: Diphyllobothriidea).

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Barčák,Aneta Yoneva,Hana Sehadová,Mikuláš Oros,Andrea Gustinelli,Roman Kuchta

PloS one 11:e0165649 PubMed27792762

2016

Development of the Nervous System of Carinina ochracea (Palaeonemer-tea, Nemertea).

Applications

ICC/IF, IHC

Species

Unspecified reactive species, Unspecified reactive species

Jörn von Döhren

Biology open 3:50-8 PubMed24326188

2014

Differential expression of the FMRF gene in adult and hatchling stellate ganglia of the squid Loligo pealei.

Applications

IHC

Species

Unspecified reactive species

J Peter H Burbach,Philip Grant,Anita J C G M Hellemons,Joseph A Degiorgis,Ka Wan Li,Harish C Pant

EvoDevo 2:12 PubMed21631916

2011

Multiple Sox genes are expressed in stem cells or in differentiating neuro-sensory cells in the hydrozoan Clytia hemisphaerica.

Applications

ICC/IF

Species

Unspecified reactive species

Muriel Jager,Eric Quéinnec,Hervé Le Guyader,Michaël Manuel

PloS one 4:e4231 PubMed19156208

2009

Are Hox genes ancestrally involved in axial patterning? Evidence from the hydrozoan Clytia hemisphaerica (Cnidaria).

Applications

IHC-Fr

Species

Unspecified reactive species

Roxane Chiori,Muriel Jager,Elsa Denker,Patrick Wincker,Corinne Da Silva,Hervé Le Guyader,Michaël Manuel,Eric Quéinnec
View all publications
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Product promise

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