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AB35336

Anti-NPY1R antibody

4

(2 Reviews)

|

(4 Publications)

Sheep Polyclonal NPY1R antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human NPY1R aa 350 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

NPYR, NPYY1, NPY1R, Neuropeptide Y receptor type 1, NPY1-R

1 Images
Western blot - Anti-NPY1R antibody (AB35336)
  • WB

Supplier Data

Western blot - Anti-NPY1R antibody (AB35336)

All lanes:

Western blot - Anti-NPY1R antibody (ab35336)

All lanes:

Human Brain Lysate

Predicted band size: 44 kDa

false

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human NPY1R aa 350 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P25929

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Alternative Products

Primary Antibodies

AB183108

Anti-NPY1R antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY1R antibody - C-terminal (AB183108)

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  • 0
Primary Antibodies

AB216966

Anti-NPY1R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY1R antibody (AB216966)

  • 0
  • 0
Primary Antibodies

AB219266

Anti-NPY1R antibody - Cytoplasmic domain

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY1R antibody - Cytoplasmic domain (AB219266)

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  • 0

Complementary Products

Primary Antibodies

AB30914

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neuropeptide Y antibody (AB30914)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB15580

Anti-Ki67 antibody

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Primary Antibodies

AB283568

Anti-CGRP-I+CGRP-II antibody [EPR23804-95]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CGRP-I+CGRP-II antibody [EPR23804-95] (AB283568)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Ammonium Sulphate fractionation.
Storage buffer
pH: 7.2 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuropeptide Y receptor Y1 (NPY1R) also known simply as NPY1R is a G protein-coupled receptor involved in the mechanical action of neuropeptide Y peptide YY and pancreatic polypeptide. It weighs approximately 48 kDa. This receptor is mostly expressed in the central nervous system including the hypothalamus as well as regions like the amygdala. It also appears in peripheral tissues such as the heart blood vessels and kidneys.
Biological function summary

NPY1R plays a role in regulating various physiological processes. As a part of the neuropeptide Y receptor family it helps control food intake anxiety and circadian rhythms. NPY1R influences energy homeostasis and mediates vasoconstriction. This receptor plays an essential role in stress responses where its activation can help modulate the body’s response to stressful stimuli.

Pathways

NPY1R functions in pathways like the neuropeptide Y pathway and the hypothalamic-pituitary-adrenal (HPA) axis. In the neuropeptide Y pathway NPY1R interacts with other receptors such as NPY2R and NPY5R facilitating the signaling cascades that influence appetite and energy balance. NPY1R impacts the HPA axis by affecting cortisol release integrating signals that control stress responses.

NPY1R has been implicated in conditions such as obesity and anxiety disorders. The receptor's role in regulating food intake and energy homeostasis links it to the development of obesity. Anxiety disorders connect to NPY1R through its modulation of stress responses where its interaction with proteins such as corticotropin-releasing hormone (CRH) receptors can further influence anxiety symptoms and stress management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
See full target information NPY1R
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in endocrinology 11:583105 PubMed33240219

2020

Inhibition of Y1 Receptor Promotes Osteogenesis in Bone Marrow Stromal Cells cAMP/PKA/CREB Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Yu,Fan-Cheng Chen,Wen-Ning Xu,Sheng-Long Ding,Peng-Bo Chen,Lei Yang,Sheng-Dan Jiang,Xiao-Yun Pan

Neurospine 17:69-76 PubMed32252156

2020

Rabbit Annulus Fibrosus Cells Express Neuropeptide Y, Which Is Influenced by Mechanical and Inflammatory Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Malcolm E Dombrowski,Adam S Olsen,Nicholas Vaudreuil,Brandon K Couch,Qing Dong,Michelle Tucci,Joon Y Lee,Nam V Vo,Gwendolyn Sowa

Cephalalgia : an international journal of headache 37:1350-1372 PubMed27852962

2016

Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine.

Applications

Unspecified application

Species

Unspecified reactive species

Frank L Rice,Jennifer Y Xie,Phillip J Albrecht,Emily Acker,Justin Bourgeois,Edita Navratilova,David W Dodick,Frank Porreca

Archives of oral biology 54:258-62 PubMed19010457

2008

Neuropeptide Y (NPY) and NPY Y1 receptor in periodontal health and disease.

Applications

Unspecified application

Species

Unspecified reactive species

Fionnuala T Lundy,Ikhlas A El Karim,Gerard J Linden
View all publications
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Product promise

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