AB219266

Anti-NPY1R antibody - Cytoplasmic domain

Name: Anti-NPY1R antibody - Cytoplasmic domain (ab219266) | Abcam
Brand: Abcam Limited
SKU: AB219266
Price: 605 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal NPY1R antibody. Cytoplasmic domain. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NPY1R.

View Alternative Names

NPYR, NPYY1, NPY1R, Neuropeptide Y receptor type 1, NPY1-R

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY1R antibody - Cytoplasmic domain (AB219266)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY1R antibody - Cytoplasmic domain (AB219266)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin (Melanoma) tissue labeling NPY1R with ab219266 at 16 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY1R antibody - Cytoplasmic domain (AB219266)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue labeling NPY1R with ab219266 at 16 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY1R antibody - Cytoplasmic domain (AB219266)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin (Melanoma) tissue labeling NPY1R with ab219266 at 16 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human NPY1R. The exact immunogen used to generate this antibody is proprietary information.

P25929

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except NPY6R (61%).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "16 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Sheep": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.099% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuropeptide Y receptor Y1 (NPY1R) also known simply as NPY1R is a G protein-coupled receptor involved in the mechanical action of neuropeptide Y peptide YY and pancreatic polypeptide. It weighs approximately 48 kDa. This receptor is mostly expressed in the central nervous system including the hypothalamus as well as regions like the amygdala. It also appears in peripheral tissues such as the heart blood vessels and kidneys.

Biological function summary

NPY1R plays a role in regulating various physiological processes. As a part of the neuropeptide Y receptor family it helps control food intake anxiety and circadian rhythms. NPY1R influences energy homeostasis and mediates vasoconstriction. This receptor plays an essential role in stress responses where its activation can help modulate the body’s response to stressful stimuli.

Pathways

NPY1R functions in pathways like the neuropeptide Y pathway and the hypothalamic-pituitary-adrenal (HPA) axis. In the neuropeptide Y pathway NPY1R interacts with other receptors such as NPY2R and NPY5R facilitating the signaling cascades that influence appetite and energy balance. NPY1R impacts the HPA axis by affecting cortisol release integrating signals that control stress responses.

NPY1R has been implicated in conditions such as obesity and anxiety disorders. The receptor's role in regulating food intake and energy homeostasis links it to the development of obesity. Anxiety disorders connect to NPY1R through its modulation of stress responses where its interaction with proteins such as corticotropin-releasing hormone (CRH) receptors can further influence anxiety symptoms and stress management.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

See full target information NPY1R

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 15:10389-10406 PubMed37801482

2023

Novel diagnostic biomarkers of oxidative stress, immunological characterization and experimental validation in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Di Hu,Xiaocong Mo,Luo Jihang,Cheng Huang,Hesong Xie,Ling Jin

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-NPY1R antibody - Cytoplasmic domain

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY1R antibody - Cytoplasmic domain (AB219266)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY1R antibody - Cytoplasmic domain (AB219266)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY1R antibody - Cytoplasmic domain (AB219266)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise