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AB59137

Anti-NPY2R/Y2 receptor antibody

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(1 Publication)

Goat Polyclonal NPY2R/Y2 receptor antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Npy2r aa 350 to C-terminus.

View Alternative Names

Neuropeptide Y receptor type 2, NPY2-R, NPY-Y2 receptor, Y2 receptor

1 Images
Western blot - Anti-NPY2R/Y2 receptor antibody (AB59137)
  • WB

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Western blot - Anti-NPY2R/Y2 receptor antibody (AB59137)

All lanes:

Western blot - Anti-NPY2R/Y2 receptor antibody (ab59137) at 0.1 µg/mL

All lanes:

Rat brain lysate in RIPA buffer at 35 µg

Predicted band size: 43 kDa

Observed band size: 40 kDa,45 kDa

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Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Mouse Npy2r aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P97295

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NPY2R also known as the Y2 receptor is a G-protein coupled receptor with a molecular mass of approximately 42 kDa. It primarily binds neuropeptide Y (NPY) peptide YY (PYY) and pancreatic polypeptide (PP). The NPY2R is expressed in the central nervous system particularly in the brain regions like the hypothalamus and hippocampus as well as in peripheral tissues such as vascular smooth muscle and the gastrointestinal tract.
Biological function summary

The NPY2R is involved in processes like appetite regulation anxiety and blood pressure control. When activated by its ligands NPY2R plays a role in reducing neurotransmitter release which translates into modulation of neuronal activity and vascular tone. It does not form part of a larger complex but functions by itself to exert its biological roles.

Pathways

NPY2R participates in the neuropeptide signaling pathway and is linked to the regulation of energy homeostasis. Through its interactions NPY2R influences the action of other receptors such as the Y1 receptor both contributing to the complex regulation of food intake and stress responses. The Y2 receptor also affects the sympathetic nervous system through the modulation of noradrenaline release.

NPY2R shows a connection with obesity and hypertension. Abnormal Y2 receptor function could lead to disrupted energy balance and increased appetite contributing to obesity. In hypertension altered NPY2R activity may lead to dysfunctional blood pressure regulation. Connections with proteins like Y1 receptor also underpin its relevance in these conditions as they together orchestrate the cardiovascular and metabolic responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for neuropeptide Y and peptide YY.
See full target information Npy2r
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Food & nutrition research 61:1290740 PubMed28326005

2017

Bioactivity of food peptides: biological response of rats to bovine milk whey peptides following acute exercise.

Applications

Unspecified application

Species

Unspecified reactive species

Carolina Soares Moura,Pablo Christiano Barboza Lollo,Priscila Neder Morato,Eder Muller Risso,Jaime Amaya-Farfan
View all publications
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Product promise

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