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AB223515

Anti-NPY6R antibody

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(1 Publication)

Rabbit Polyclonal NPY6R antibody. Suitable for ICC/IF, IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NPY6R aa 1-50.

View Alternative Names

NPY1RL, Y2B, NPY6R, Putative neuropeptide Y receptor type 6, NPY6-R, NPY Y1-like receptor, Putative pancreatic polypeptide receptor 2, PP2

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY6R antibody (AB223515)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY6R antibody (AB223515)

Paraffin-embedded human skeletal muscle tissue stained for NPY6R using ab223515 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY6R antibody (AB223515)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPY6R antibody (AB223515)

Paraffin-embedded human kidney tissue stained for NPY6R using ab223515 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-NPY6R antibody (AB223515)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NPY6R antibody (AB223515)

MCF7 (human breast adenocarcinoma cell line) cells stained for NPY6R (green) using ab223515 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human NPY6R aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q99463

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" }, "Rat": { "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuropeptide Y receptor type 6 (NPY6R) also called NPY6 receptor is a protein involved in signal transduction. It has a mass of roughly 50 kilodaltons. NPY6R is expressed in several tissues including the central nervous system and gastrointestinal tract. Researchers have identified its role in regulating physiological responses influenced by neuropeptide Y and peptide YY which are its primary ligands.
Biological function summary

NPY6R modulates appetite and energy balance. It forms part of a receptor complex that interacts with G-proteins to mediate its effects. By binding to its ligands it influences processes such as feeding behavior and gut functionality. NPY6R's activity regulates energy intake and may affect fat storage contributing to its biological functions.

Pathways

NPY6R plays a significant role in the neuropeptide Y signaling pathway and the hypothalamic-pituitary-adrenal (HPA) axis. These pathways manage stress response and energy homeostasis. NPY6R has interactions with other neuropeptide Y receptors such as NPY1R and NPY2R which collaborate in these metabolic and stress-related pathways.

NPY6R is associated with obesity and anxiety disorders. Its involvement in regulating appetite and energy balance links it to obesity research. Additionally alterations in NPY6R signaling may cause anxiety-related conditions with potential interactions involving corticotropin-releasing hormone receptor highlighting its broader impact on mental health pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function.
See full target information NPY6R
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Redox biology 24:101211 PubMed31108460

2019

Ferroptosis is governed by differential regulation of transcription in liver cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Zhang,Lutao Du,Yongxia Qiao,Xiaobai Zhang,Weisheng Zheng,Qi Wu,Yan Chen,Guoqing Zhu,Ya Liu,Zhixuan Bian,Susu Guo,Yueyue Yang,Lifang Ma,Yongchun Yu,Qiuhui Pan,Fenyong Sun,Jiayi Wang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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